Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics

Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics

Phenome-Wide Association Studies (PheWAS) investigate whether genetic polymorphisms associated with a phenotype are also associated with other diagnoses. In this study, we have developed new methods to perform a PheWAS based on ICD-10 codes and biological test results, and to use a quantitative trai...

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Bibliographic Details
Main Authors: Neuraz, Antoine, Chouchana, Laurent, Malamut, Georgia, Le Beller, Christine, Roche, Denis, Beaune, Philippe, Degoulet, Patrice, Burgun, Anita, Loriot, Marie-Anne, Avillach, Paul
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873228/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873228/

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