Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer
Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs...
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Public Library of Science
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871845/ |
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pubmed-3871845 |
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pubmed-38718452013-12-27 Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer Kang, Guhyun Hwang, Woo Cheol Do, In-Gu Wang, Kai Kang, So Young Lee, Jeeyun Park, Se Hoon Park, Joon Oh Kang, Won Ki Jang, Jiryeon Choi, Min-Gew Lee, Jun Ho Sohn, Tae Sung Bae, Jae Moon Kim, Sung Kim, Min Ji Kim, Seonwoo Park, Cheol Keun Kim, Kyoung-Mee Research Article Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs and AGCs are distinct entities or whether EGCs are the beginning stages of AGCs. We performed whole exome sequencing of four samples from patients with EGC and compared the results with those from AGCs. In both EGCs and AGCs, a total of 268 genes were commonly mutated and independent mutations were additionally found in EGCs (516 genes) and AGCs (3104 genes). A higher frequency of C>G transitions was observed in intestinal-type compared to diffuse-type carcinomas (P = 0.010). The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis. Public Library of Science 2013-12-23 /pmc/articles/PMC3871845/ /pubmed/24376576 http://dx.doi.org/10.1371/journal.pone.0082770 Text en © 2013 Kang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kang, Guhyun Hwang, Woo Cheol Do, In-Gu Wang, Kai Kang, So Young Lee, Jeeyun Park, Se Hoon Park, Joon Oh Kang, Won Ki Jang, Jiryeon Choi, Min-Gew Lee, Jun Ho Sohn, Tae Sung Bae, Jae Moon Kim, Sung Kim, Min Ji Kim, Seonwoo Park, Cheol Keun Kim, Kyoung-Mee |
| spellingShingle |
Kang, Guhyun Hwang, Woo Cheol Do, In-Gu Wang, Kai Kang, So Young Lee, Jeeyun Park, Se Hoon Park, Joon Oh Kang, Won Ki Jang, Jiryeon Choi, Min-Gew Lee, Jun Ho Sohn, Tae Sung Bae, Jae Moon Kim, Sung Kim, Min Ji Kim, Seonwoo Park, Cheol Keun Kim, Kyoung-Mee Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer |
| author_facet |
Kang, Guhyun Hwang, Woo Cheol Do, In-Gu Wang, Kai Kang, So Young Lee, Jeeyun Park, Se Hoon Park, Joon Oh Kang, Won Ki Jang, Jiryeon Choi, Min-Gew Lee, Jun Ho Sohn, Tae Sung Bae, Jae Moon Kim, Sung Kim, Min Ji Kim, Seonwoo Park, Cheol Keun Kim, Kyoung-Mee |
| author_sort |
Kang, Guhyun |
| title |
Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer |
| title_short |
Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer |
| title_full |
Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer |
| title_fullStr |
Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer |
| title_full_unstemmed |
Exome Sequencing Identifies Early Gastric Carcinoma as an Early Stage of Advanced Gastric Cancer |
| title_sort |
exome sequencing identifies early gastric carcinoma as an early stage of advanced gastric cancer |
| description |
Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs and AGCs are distinct entities or whether EGCs are the beginning stages of AGCs. We performed whole exome sequencing of four samples from patients with EGC and compared the results with those from AGCs. In both EGCs and AGCs, a total of 268 genes were commonly mutated and independent mutations were additionally found in EGCs (516 genes) and AGCs (3104 genes). A higher frequency of C>G transitions was observed in intestinal-type compared to diffuse-type carcinomas (P = 0.010). The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis. |
| publisher |
Public Library of Science |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871845/ |
| _version_ |
1612041129041068032 |