Cilengitide-Induced Temporal Variations in Transvascular Transfer Parameters of Tumor Vasculature in a Rat Glioma Model: Identifying Potential MRI Biomarkers of Acute Effects

Increased efficacy of radiotherapy (RT) 4-8 h after Cilengitide treatment has been reported. We hypothesized that the effects of Cilengitide on tumor transvascular transfer parameters might underlie, and thus predict, this potentiation. Athymic rats with orthotopic U251 glioma were studied at ~21 da...

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Bibliographic Details
Main Authors: Nagaraja, Tavarekere N., Aryal, Madhava P., Brown, Stephen L., Bagher-Ebadian, Hassan, Mikkelsen, Tom, Yang, James J., Panda, Swayamprava, Keenan, Kelly A., Cabral, Glauber, Ewing, James R.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871527/