Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)

Naked mole-rats have a variety of distinctive features such as the organization of a hierarchical society (known as eusociality), extraordinary longevity, and cancer resistance; thus, it would be worthwhile investigating these animals in detail. One important task is the preparation of a brain atlas...

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Main Authors:	Seki, Fumiko, Hikishima, Keigo, Nambu, Sanae, Okanoya, Kazuo, Okano, Hirotaka J., Sasaki, Erika, Miura, Kyoko, Okano, Hideyuki
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868886/

id	pubmed-3868886
recordtype	oai_dc
spelling	pubmed-38688862014-01-03 Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber) Seki, Fumiko Hikishima, Keigo Nambu, Sanae Okanoya, Kazuo Okano, Hirotaka J. Sasaki, Erika Miura, Kyoko Okano, Hideyuki Neuroscience Naked mole-rats have a variety of distinctive features such as the organization of a hierarchical society (known as eusociality), extraordinary longevity, and cancer resistance; thus, it would be worthwhile investigating these animals in detail. One important task is the preparation of a brain atlas database that provide comprehensive information containing multidimensional data with various image contrasts, which can be achievable using a magnetic resonance imaging (MRI). Advanced MRI techniques such as diffusion tensor imaging (DTI), which generates high contrast images of fiber structures, can characterize unique morphological properties in addition to conventional MRI. To obtain high spatial resolution images, MR histology, DTI, and X-ray computed tomography were performed on the fixed adult brain. Skull and brain structures were segmented as well as reconstructed in stereotaxic coordinates. Data were also acquired for the neonatal brain to allow developmental changes to be observed. Moreover, in vivo imaging of naked mole-rats was established as an evaluation tool of live animals. The data obtained comprised three-dimensional (3D) images with high tissue contrast as well as stereotaxic coordinates. Developmental differences in the visual system were highlighted in particular by DTI. Although it was difficult to delineate optic nerves in the mature adult brain, parts of them could be distinguished in the immature neonatal brain. From observation of cortical thickness, possibility of high somatosensory system development replaced to the visual system was indicated. 3D visualization of brain structures in the atlas as well as the establishment of in vivo imaging would promote neuroimaging researches towards detection of novel characteristics of eusocial naked mole-rats. Frontiers Media S.A. 2013-12-20 /pmc/articles/PMC3868886/ /pubmed/24391551 http://dx.doi.org/10.3389/fnana.2013.00045 Text en Copyright © 2013 Seki, Hikishima, Nambu, Okanoya, Okano, Sasaki, Miura and Okano. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Seki, Fumiko Hikishima, Keigo Nambu, Sanae Okanoya, Kazuo Okano, Hirotaka J. Sasaki, Erika Miura, Kyoko Okano, Hideyuki
spellingShingle	Seki, Fumiko Hikishima, Keigo Nambu, Sanae Okanoya, Kazuo Okano, Hirotaka J. Sasaki, Erika Miura, Kyoko Okano, Hideyuki Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)
author_facet	Seki, Fumiko Hikishima, Keigo Nambu, Sanae Okanoya, Kazuo Okano, Hirotaka J. Sasaki, Erika Miura, Kyoko Okano, Hideyuki
author_sort	Seki, Fumiko
title	Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)
title_short	Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)
title_full	Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)
title_fullStr	Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)
title_full_unstemmed	Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)
title_sort	multidimensional mri-ct atlas of the naked mole-rat brain (heterocephalus glaber)
description	Naked mole-rats have a variety of distinctive features such as the organization of a hierarchical society (known as eusociality), extraordinary longevity, and cancer resistance; thus, it would be worthwhile investigating these animals in detail. One important task is the preparation of a brain atlas database that provide comprehensive information containing multidimensional data with various image contrasts, which can be achievable using a magnetic resonance imaging (MRI). Advanced MRI techniques such as diffusion tensor imaging (DTI), which generates high contrast images of fiber structures, can characterize unique morphological properties in addition to conventional MRI. To obtain high spatial resolution images, MR histology, DTI, and X-ray computed tomography were performed on the fixed adult brain. Skull and brain structures were segmented as well as reconstructed in stereotaxic coordinates. Data were also acquired for the neonatal brain to allow developmental changes to be observed. Moreover, in vivo imaging of naked mole-rats was established as an evaluation tool of live animals. The data obtained comprised three-dimensional (3D) images with high tissue contrast as well as stereotaxic coordinates. Developmental differences in the visual system were highlighted in particular by DTI. Although it was difficult to delineate optic nerves in the mature adult brain, parts of them could be distinguished in the immature neonatal brain. From observation of cortical thickness, possibility of high somatosensory system development replaced to the visual system was indicated. 3D visualization of brain structures in the atlas as well as the establishment of in vivo imaging would promote neuroimaging researches towards detection of novel characteristics of eusocial naked mole-rats.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868886/
_version_	1612040172580372480

Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)

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