SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

Efficient coupling of cellular energy production to metabolic demand is crucial to maintain organismal homeostasis. Here, we report that the mitochondrial Sirtuin Sirt4 regulates mitochondrial ATP homeostasis. We find that Sirt4 affects mitochondrial uncoupling via the adenine nucleotide translocato...

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Bibliographic Details
Main Authors: Ho, Linh, Titus, Allen Sam, Banerjee, Kushal Kr, George, Suji, Lin, Wei, Deota, Shaunak, Saha, Asish K., Nakamura, Ken, Gut, Philipp, Verdin, Eric, Kolthur-Seetharam, Ullas
Format: Online
Language:English
Published: Impact Journals LLC 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868726/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868726/

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