Hypogonadism and erectile dysfunction in myotonic dystrophy type 1

Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults. It affects many organs and systems besides muscle. Aim of this study was to assess frequency of erectile dysfunction (ED) and hypogonadism, the correlation between them and the impact of ED on quality of life (Q...

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Main Authors:	PERIC, STOJAN, NISIC, TANJA, MILICEV, MILENA, BASTA, IVANA, MARJANOVIC, IVAN, PERIC, MARINA, LAVRNIC, DRAGANA, RAKOCEVIC STOJANOVIC, VIDOSAVA
Format:	Online
Language:	English
Published:	Pacini Editore SpA 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866901/

id	pubmed-3866901
recordtype	oai_dc
spelling	pubmed-38669012014-01-07 Hypogonadism and erectile dysfunction in myotonic dystrophy type 1 PERIC, STOJAN NISIC, TANJA MILICEV, MILENA BASTA, IVANA MARJANOVIC, IVAN PERIC, MARINA LAVRNIC, DRAGANA RAKOCEVIC STOJANOVIC, VIDOSAVA Original Articles Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults. It affects many organs and systems besides muscle. Aim of this study was to assess frequency of erectile dysfunction (ED) and hypogonadism, the correlation between them and the impact of ED on quality of life (QoL) in patients with DM1. A series of 25 men (aged from 22 to 58 years) with a diagnosis of DM1 was analyzed. Muscular Impairment Rating Scale (MIRS) was used to assess severity of muscular involvement. Erectile function was assessed using the short form of the International Index of Erectile Function test (IIEF-5). Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were assessed. All patients completed the Serbian version of the SF-36 questionnaire as a measure of health-related QoL. ED was present in 18 (72%) of patients. Seven (28%) patients were euogonadic, 16 (64%) had compensated hypogonadism and 2 (8%) had primary hypogonadism. ED was somewhat more common in patients with hypogonadism (78% vs. 57%). Mental composite score of SF-36 was lower in patients with ED (p<0.05). Our results showed that 72% of men with DM1 had ED and hypogonadism. Studies with larger number of subjects are needed to resolve cascade of events that lays behind ED in DM1. Development of therapeutic strategies may have positive impact on QoL. Substitutive therapy with androgens may be benefitial. Pacini Editore SpA 2013-10 /pmc/articles/PMC3866901/ /pubmed/24399868 Text en The journal and the individual contributions contained in it are protected by the copyright of Gaetano Conte Academy, Naples, Italy http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	PERIC, STOJAN NISIC, TANJA MILICEV, MILENA BASTA, IVANA MARJANOVIC, IVAN PERIC, MARINA LAVRNIC, DRAGANA RAKOCEVIC STOJANOVIC, VIDOSAVA
spellingShingle	PERIC, STOJAN NISIC, TANJA MILICEV, MILENA BASTA, IVANA MARJANOVIC, IVAN PERIC, MARINA LAVRNIC, DRAGANA RAKOCEVIC STOJANOVIC, VIDOSAVA Hypogonadism and erectile dysfunction in myotonic dystrophy type 1
author_facet	PERIC, STOJAN NISIC, TANJA MILICEV, MILENA BASTA, IVANA MARJANOVIC, IVAN PERIC, MARINA LAVRNIC, DRAGANA RAKOCEVIC STOJANOVIC, VIDOSAVA
author_sort	PERIC, STOJAN
title	Hypogonadism and erectile dysfunction in myotonic dystrophy type 1
title_short	Hypogonadism and erectile dysfunction in myotonic dystrophy type 1
title_full	Hypogonadism and erectile dysfunction in myotonic dystrophy type 1
title_fullStr	Hypogonadism and erectile dysfunction in myotonic dystrophy type 1
title_full_unstemmed	Hypogonadism and erectile dysfunction in myotonic dystrophy type 1
title_sort	hypogonadism and erectile dysfunction in myotonic dystrophy type 1
description	Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults. It affects many organs and systems besides muscle. Aim of this study was to assess frequency of erectile dysfunction (ED) and hypogonadism, the correlation between them and the impact of ED on quality of life (QoL) in patients with DM1. A series of 25 men (aged from 22 to 58 years) with a diagnosis of DM1 was analyzed. Muscular Impairment Rating Scale (MIRS) was used to assess severity of muscular involvement. Erectile function was assessed using the short form of the International Index of Erectile Function test (IIEF-5). Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were assessed. All patients completed the Serbian version of the SF-36 questionnaire as a measure of health-related QoL. ED was present in 18 (72%) of patients. Seven (28%) patients were euogonadic, 16 (64%) had compensated hypogonadism and 2 (8%) had primary hypogonadism. ED was somewhat more common in patients with hypogonadism (78% vs. 57%). Mental composite score of SF-36 was lower in patients with ED (p<0.05). Our results showed that 72% of men with DM1 had ED and hypogonadism. Studies with larger number of subjects are needed to resolve cascade of events that lays behind ED in DM1. Development of therapeutic strategies may have positive impact on QoL. Substitutive therapy with androgens may be benefitial.
publisher	Pacini Editore SpA
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866901/
_version_	1612039526358712320

Hypogonadism and erectile dysfunction in myotonic dystrophy type 1

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