Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma

Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma

Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cells against tumors. However, the potential for inser...

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Bibliographic Details
Main Authors: Budde, Lihua E., Berger, Carolina, Lin, Yukang, Wang, Jinjuan, Lin, Xubin, Frayo, Shani E., Brouns, Shaunda A., Spencer, David M., Till, Brian G., Jensen, Michael C., Riddell, Stanley R., Press, Oliver W.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866194/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866194/

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