The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair
Introduction. Ruptured abdominal aortic aneurysm (rAAA) causes a significant inflammatory response. The study aims to investigate this response following endovascular and open repair of ruptured AAA. Patients and Methods. Consecutive rAAA patients had either endovascular aneurysm repair (EVAR) or o...
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Hindawi Publishing Corporation
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865732/ |
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pubmed-38657322013-12-22 The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair Makar, R. R. Badger, S. A. O'Donnell, M. E. Soong, C. V. Lau, L. L. Young, I. S. Hannon, R. J. Lee, B. Clinical Study Introduction. Ruptured abdominal aortic aneurysm (rAAA) causes a significant inflammatory response. The study aims to investigate this response following endovascular and open repair of ruptured AAA. Patients and Methods. Consecutive rAAA patients had either endovascular aneurysm repair (EVAR) or open repair (OR). Blood samples were taken for cytokines, lipid hydroperoxides (LOOH), antioxidants, and neutrophil elastase/α1-anti-trypsin complexes (NE/AAT) before surgery, 6 hours after clamp release and 1, 3, 5 days postoperatively. Results. 30 patients were included in the study, with 14 undergoing eEVAR and 16 eOR, with comparable baseline comorbidities, age, and parameters. IL-6 peaked higher in eOR patients (P = 0.04), while p75TNFr was similar between groups except at day 5 (P = 0.04). The NE/AAT concentrations were higher in eOR patients (P = 0.01), particularly in the first postoperative day, and correlated with blood (r = 0.398, P = 0.029) and platelet (r = 0.424, P = 0.020) volume transfused. C-reactive protein rose and lipid hydroperoxide fell in both groups without significant intergroup difference. Vitamins C and E, lycopene, and β-carotene levels were similar between groups. Conclusion. EVAR is associated with lower systemic inflammatory response compared to OR. Its increased future use may thereby improve outcomes for patients. Hindawi Publishing Corporation 2013 2013-12-02 /pmc/articles/PMC3865732/ /pubmed/24363936 http://dx.doi.org/10.1155/2013/482728 Text en Copyright © 2013 R. R. Makar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Makar, R. R. Badger, S. A. O'Donnell, M. E. Soong, C. V. Lau, L. L. Young, I. S. Hannon, R. J. Lee, B. |
| spellingShingle |
Makar, R. R. Badger, S. A. O'Donnell, M. E. Soong, C. V. Lau, L. L. Young, I. S. Hannon, R. J. Lee, B. The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair |
| author_facet |
Makar, R. R. Badger, S. A. O'Donnell, M. E. Soong, C. V. Lau, L. L. Young, I. S. Hannon, R. J. Lee, B. |
| author_sort |
Makar, R. R. |
| title |
The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair |
| title_short |
The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair |
| title_full |
The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair |
| title_fullStr |
The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair |
| title_full_unstemmed |
The Inflammatory Response to Ruptured Abdominal Aortic Aneurysm Is Altered by Endovascular Repair |
| title_sort |
inflammatory response to ruptured abdominal aortic aneurysm is altered by endovascular repair |
| description |
Introduction. Ruptured abdominal aortic aneurysm (rAAA) causes a significant inflammatory response. The study aims to investigate this response following endovascular and open repair of ruptured AAA. Patients and Methods.
Consecutive rAAA patients had either endovascular aneurysm repair (EVAR) or open repair (OR). Blood samples were taken for cytokines, lipid hydroperoxides (LOOH), antioxidants, and neutrophil elastase/α1-anti-trypsin complexes (NE/AAT) before surgery, 6 hours after clamp release and 1, 3, 5 days postoperatively. Results. 30 patients were included in the study, with 14 undergoing eEVAR and 16 eOR, with comparable baseline comorbidities, age, and parameters. IL-6 peaked higher in eOR patients (P = 0.04), while p75TNFr was similar between groups except at day 5 (P = 0.04). The NE/AAT concentrations were higher in eOR patients (P = 0.01), particularly in the first postoperative day, and correlated with blood (r = 0.398, P = 0.029) and platelet (r = 0.424, P = 0.020) volume transfused. C-reactive protein rose and lipid hydroperoxide fell in both groups without significant intergroup difference. Vitamins C and E, lycopene, and β-carotene levels were similar between groups. Conclusion. EVAR is associated with lower systemic inflammatory response compared to OR. Its increased future use may thereby improve outcomes for patients. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865732/ |
| _version_ |
1612039108356472832 |