Autism: Metabolism, Mitochondria, and the Microbiome

Autism: Metabolism, Mitochondria, and the Microbiome

New approaches are needed to examine the diverse symptoms and comorbidities of the growing family of neurodevelopmental disorders known as autism spectrum disorder (ASD). ASD originally was thought to be a static, inheritable neurodevelopmental disorder, and our understanding of it is undergoing a m...

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Main Author: MacFabe, Derrick
Format: Online
Language:English
Published: Global Advances in Health and Medicine 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865378/
id pubmed-3865378
recordtype oai_dc
spelling pubmed-38653782014-11-01 Autism: Metabolism, Mitochondria, and the Microbiome MacFabe, Derrick Original Article New approaches are needed to examine the diverse symptoms and comorbidities of the growing family of neurodevelopmental disorders known as autism spectrum disorder (ASD). ASD originally was thought to be a static, inheritable neurodevelopmental disorder, and our understanding of it is undergoing a major shift. It is emerging as a dynamic system of metabolic and immune anomalies involving many organ systems, including the brain, and environmental exposure. The initial detailed observation and inquiry of patients with ASD and related conditions and the histories of their caregivers and families have been invaluable. How gastrointestinal (GI) factors are related to ASD is not yet clear. Nevertheless, many patients with ASD have a history of previous antibiotic exposure or hospitalization, GI symptoms, abnormal food cravings, and unique intestinal bacterial populations, which have been proposed to relate to variable symptom severity. Global Advances in Health and Medicine 2013-11 2013-11-01 /pmc/articles/PMC3865378/ /pubmed/24416709 http://dx.doi.org/10.7453/gahmj.2013.089 Text en © 2013 GAHM LLC. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial- No Derivative 3.0 License, which permits rights to copy, distribute and transmit the work for noncommercial purposes only, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author MacFabe, Derrick
spellingShingle MacFabe, Derrick
Autism: Metabolism, Mitochondria, and the Microbiome
author_facet MacFabe, Derrick
author_sort MacFabe, Derrick
title Autism: Metabolism, Mitochondria, and the Microbiome
title_short Autism: Metabolism, Mitochondria, and the Microbiome
title_full Autism: Metabolism, Mitochondria, and the Microbiome
title_fullStr Autism: Metabolism, Mitochondria, and the Microbiome
title_full_unstemmed Autism: Metabolism, Mitochondria, and the Microbiome
title_sort autism: metabolism, mitochondria, and the microbiome
description New approaches are needed to examine the diverse symptoms and comorbidities of the growing family of neurodevelopmental disorders known as autism spectrum disorder (ASD). ASD originally was thought to be a static, inheritable neurodevelopmental disorder, and our understanding of it is undergoing a major shift. It is emerging as a dynamic system of metabolic and immune anomalies involving many organ systems, including the brain, and environmental exposure. The initial detailed observation and inquiry of patients with ASD and related conditions and the histories of their caregivers and families have been invaluable. How gastrointestinal (GI) factors are related to ASD is not yet clear. Nevertheless, many patients with ASD have a history of previous antibiotic exposure or hospitalization, GI symptoms, abnormal food cravings, and unique intestinal bacterial populations, which have been proposed to relate to variable symptom severity.
publisher Global Advances in Health and Medicine
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865378/
_version_ 1612038996209172480

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