Structure of a pseudokinase domain switch that controls oncogenic activation of Jak kinases

Structure of a pseudokinase domain switch that controls oncogenic activation of Jak kinases

The V617F mutation in the Jak2 pseudokinase domain causes myeloproliferative neoplasms, and the equivalent mutation in Jak1 (V658F) is found in T-cell leukemias. Crystal structures of wild type and V658F mutant human Jak1 pseudokinase reveal a conformational switch that remodels a linker segment enc...

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Bibliographic Details
Main Authors: Toms, Angela V., Deshpande, Anagha, McNally, Randall, Jeong, Youngjee, Rogers, Julia M., Kim, Chae Un, Gruner, Sol M., Ficarro, Scott B., Marto, Jarrod A., Sattler, Martin, Griffin, James D., Eck, Michael J.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863620/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863620/

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