The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers

The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers

The “endocannabinoid system (ECS)” comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system. Recent evidence suggests that both cann...

Full description

Bibliographic Details
Main Authors: Ayakannu, Thangesweran, Taylor, Anthony H., Marczylo, Timothy H., Willets, Jonathon M., Konje, Justin C.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863507/
id pubmed-3863507
recordtype oai_dc
spelling pubmed-38635072013-12-25 The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers Ayakannu, Thangesweran Taylor, Anthony H. Marczylo, Timothy H. Willets, Jonathon M. Konje, Justin C. Review Article The “endocannabinoid system (ECS)” comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system. Recent evidence suggests that both cannabinoid receptors are present in sex steroid hormone-dependent cancer tissues and potentially play an important role in those malignancies. Sex steroid hormones regulate the endocannabinoid system and the endocannabinoids prevent tumour development through putative protective mechanisms that prevent cell growth and migration, suggesting an important role for endocannabinoids in the regulation of sex hormone-dependent tumours and metastasis. Here, the role of the endocannabinoid system in sex steroid hormone-dependent cancers is described and the potential for novel therapies assessed. Hindawi Publishing Corporation 2013 2013-11-27 /pmc/articles/PMC3863507/ /pubmed/24369462 http://dx.doi.org/10.1155/2013/259676 Text en Copyright © 2013 Thangesweran Ayakannu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ayakannu, Thangesweran
Taylor, Anthony H.
Marczylo, Timothy H.
Willets, Jonathon M.
Konje, Justin C.
spellingShingle Ayakannu, Thangesweran
Taylor, Anthony H.
Marczylo, Timothy H.
Willets, Jonathon M.
Konje, Justin C.
The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
author_facet Ayakannu, Thangesweran
Taylor, Anthony H.
Marczylo, Timothy H.
Willets, Jonathon M.
Konje, Justin C.
author_sort Ayakannu, Thangesweran
title The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
title_short The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
title_full The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
title_fullStr The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
title_full_unstemmed The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers
title_sort endocannabinoid system and sex steroid hormone-dependent cancers
description The “endocannabinoid system (ECS)” comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system. Recent evidence suggests that both cannabinoid receptors are present in sex steroid hormone-dependent cancer tissues and potentially play an important role in those malignancies. Sex steroid hormones regulate the endocannabinoid system and the endocannabinoids prevent tumour development through putative protective mechanisms that prevent cell growth and migration, suggesting an important role for endocannabinoids in the regulation of sex hormone-dependent tumours and metastasis. Here, the role of the endocannabinoid system in sex steroid hormone-dependent cancers is described and the potential for novel therapies assessed.
publisher Hindawi Publishing Corporation
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863507/
_version_ 1612038479612477440

Similar Items