Regulation of Mouse NK Cell Development and Function by Cytokines

Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines. Interleukin (IL)-15 is pivotal for their development, homeostasi...

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Main Authors:	Marçais, Antoine, Viel, Sébastien, Grau, Morgan, Henry, Thomas, Marvel, Jacqueline, Walzer, Thierry
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859915/

id	pubmed-3859915
recordtype	oai_dc
spelling	pubmed-38599152013-12-27 Regulation of Mouse NK Cell Development and Function by Cytokines Marçais, Antoine Viel, Sébastien Grau, Morgan Henry, Thomas Marvel, Jacqueline Walzer, Thierry Immunology Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines. Interleukin (IL)-15 is pivotal for their development, homeostasis, and activation. Moreover, numerous other activating or inhibitory cytokines such as IL-2, IL-4, IL-7, IL-10, IL-12, IL-18, IL-21, Transforming growth factor-β (TGFβ) and type I interferons regulate their activation and their effector functions at different stages of the immune response. In this review we summarize the current understanding on the effect of these different cytokines on NK cell development, homeostasis, and functions during steady-state or upon infection by different pathogens. We try to delineate the cellular sources of these cytokines, the intracellular pathways they trigger and the transcription factors they regulate. We describe the known synergies or antagonisms between different cytokines and highlight outstanding questions in this field of investigation. Finally, we discuss how a better knowledge of cytokine action on NK cells could help improve strategies to manipulate NK cells in different clinical situations. Frontiers Media S.A. 2013-12-12 /pmc/articles/PMC3859915/ /pubmed/24376448 http://dx.doi.org/10.3389/fimmu.2013.00450 Text en Copyright © 2013 Marçais, Viel, Grau, Henry, Marvel and Walzer. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Marçais, Antoine Viel, Sébastien Grau, Morgan Henry, Thomas Marvel, Jacqueline Walzer, Thierry
spellingShingle	Marçais, Antoine Viel, Sébastien Grau, Morgan Henry, Thomas Marvel, Jacqueline Walzer, Thierry Regulation of Mouse NK Cell Development and Function by Cytokines
author_facet	Marçais, Antoine Viel, Sébastien Grau, Morgan Henry, Thomas Marvel, Jacqueline Walzer, Thierry
author_sort	Marçais, Antoine
title	Regulation of Mouse NK Cell Development and Function by Cytokines
title_short	Regulation of Mouse NK Cell Development and Function by Cytokines
title_full	Regulation of Mouse NK Cell Development and Function by Cytokines
title_fullStr	Regulation of Mouse NK Cell Development and Function by Cytokines
title_full_unstemmed	Regulation of Mouse NK Cell Development and Function by Cytokines
title_sort	regulation of mouse nk cell development and function by cytokines
description	Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines. Interleukin (IL)-15 is pivotal for their development, homeostasis, and activation. Moreover, numerous other activating or inhibitory cytokines such as IL-2, IL-4, IL-7, IL-10, IL-12, IL-18, IL-21, Transforming growth factor-β (TGFβ) and type I interferons regulate their activation and their effector functions at different stages of the immune response. In this review we summarize the current understanding on the effect of these different cytokines on NK cell development, homeostasis, and functions during steady-state or upon infection by different pathogens. We try to delineate the cellular sources of these cytokines, the intracellular pathways they trigger and the transcription factors they regulate. We describe the known synergies or antagonisms between different cytokines and highlight outstanding questions in this field of investigation. Finally, we discuss how a better knowledge of cytokine action on NK cells could help improve strategies to manipulate NK cells in different clinical situations.
publisher	Frontiers Media S.A.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859915/
_version_	1612037580469043200

Regulation of Mouse NK Cell Development and Function by Cytokines

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