Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity☆

Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity☆

Cationic amphipathic pH responsive peptides possess high in vitro and in vivo nucleic acid delivery capabilities and function by forming a non-covalent complex with cargo, protecting it from nucleases, facilitating uptake via endocytosis and responding to endosomal acidification by being released fr...

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Bibliographic Details
Main Authors: Abbate, Vincenzo, Liang, Wanling, Patel, Jayneil, Lan, Yun, Capriotti, Luigi, Iacobucci, Valentina, Bui, Tam T., Chaudhuri, Poulami, Kudsiova, Laila, Vermeer, Louic S., Chan, Patrick F.L., Kong, Xiaole, Drake, Alex F., Lam, Jenny K.W., Bansal, Sukhvinder S., Mason, A. James
Format: Online
Language:English
Published: Elsevier Science Publishers 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858832/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858832/

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