Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

A comprehensive analysis was performed to investigate how inhibition of the human bile salt export pump (BSEP/ABCB11) relates to clinically observed drug-induced liver injury (DILI). Inhibition of taurocholate (TA) transport was investigated in BSEP membrane vesicles for a data set of 250 compounds,...

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Bibliographic Details
Main Authors: Pedersen, Jenny M., Matsson, Pär, Bergström, Christel A. S., Hoogstraate, Janet, Norén, Agneta, LeCluyse, Edward L., Artursson, Per
Format: Online
Language:English
Published: Oxford University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858191/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858191/

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