The habenula governs the attribution of incentive salience to reward predictive cues
The attribution of incentive salience to reward associated cues is critical for motivation and the pursuit of rewards. Disruptions in the integrity of the neural systems controlling these processes can lead to avolition and anhedonia, symptoms that cross the diagnostic boundaries of many neuropsychi...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856853/ |
| id |
pubmed-3856853 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-38568532013-12-24 The habenula governs the attribution of incentive salience to reward predictive cues Danna, Carey L. Shepard, Paul D. Elmer, Greg I. Neuroscience The attribution of incentive salience to reward associated cues is critical for motivation and the pursuit of rewards. Disruptions in the integrity of the neural systems controlling these processes can lead to avolition and anhedonia, symptoms that cross the diagnostic boundaries of many neuropsychiatric illnesses. Here, we consider whether the habenula (Hb), a region recently demonstrated to encode negatively valenced events, also modulates the attribution of incentive salience to a neutral cue predicting a food reward. The Pavlovian autoshaping paradigm was used in the rat as an investigative tool to dissociate Pavlovian learning processes imparting strictly predictive value from learning that attributes incentive motivational value. Electrolytic lesions of the fasciculus retroflexus (fr), the sole pathway through which descending Hb efferents are conveyed, significantly increased incentive salience as measured by conditioned approaches to a cue light predictive of reward. Conversely, generation of a fictive Hb signal via fr stimulation during CS+ presentation significantly decreased the incentive salience of the predictive cue. Neither manipulation altered the reward predictive value of the cue as measured by conditioned approach to the food. Our results provide new evidence supporting a significant role for the Hb in governing the attribution of incentive motivational salience to reward predictive cues and further imply that pathological changes in Hb activity could contribute to the aberrant pursuit of debilitating goals or avolition and depression-like symptoms. Frontiers Media S.A. 2013-12-09 /pmc/articles/PMC3856853/ /pubmed/24368898 http://dx.doi.org/10.3389/fnhum.2013.00781 Text en Copyright © 2013 Danna, Shepard and Elmer. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Danna, Carey L. Shepard, Paul D. Elmer, Greg I. |
| spellingShingle |
Danna, Carey L. Shepard, Paul D. Elmer, Greg I. The habenula governs the attribution of incentive salience to reward predictive cues |
| author_facet |
Danna, Carey L. Shepard, Paul D. Elmer, Greg I. |
| author_sort |
Danna, Carey L. |
| title |
The habenula governs the attribution of incentive salience to reward predictive cues |
| title_short |
The habenula governs the attribution of incentive salience to reward predictive cues |
| title_full |
The habenula governs the attribution of incentive salience to reward predictive cues |
| title_fullStr |
The habenula governs the attribution of incentive salience to reward predictive cues |
| title_full_unstemmed |
The habenula governs the attribution of incentive salience to reward predictive cues |
| title_sort |
habenula governs the attribution of incentive salience to reward predictive cues |
| description |
The attribution of incentive salience to reward associated cues is critical for motivation and the pursuit of rewards. Disruptions in the integrity of the neural systems controlling these processes can lead to avolition and anhedonia, symptoms that cross the diagnostic boundaries of many neuropsychiatric illnesses. Here, we consider whether the habenula (Hb), a region recently demonstrated to encode negatively valenced events, also modulates the attribution of incentive salience to a neutral cue predicting a food reward. The Pavlovian autoshaping paradigm was used in the rat as an investigative tool to dissociate Pavlovian learning processes imparting strictly predictive value from learning that attributes incentive motivational value. Electrolytic lesions of the fasciculus retroflexus (fr), the sole pathway through which descending Hb efferents are conveyed, significantly increased incentive salience as measured by conditioned approaches to a cue light predictive of reward. Conversely, generation of a fictive Hb signal via fr stimulation during CS+ presentation significantly decreased the incentive salience of the predictive cue. Neither manipulation altered the reward predictive value of the cue as measured by conditioned approach to the food. Our results provide new evidence supporting a significant role for the Hb in governing the attribution of incentive motivational salience to reward predictive cues and further imply that pathological changes in Hb activity could contribute to the aberrant pursuit of debilitating goals or avolition and depression-like symptoms. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856853/ |
| _version_ |
1612036660680196096 |