Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance

Background. Pancreatic tumors are rare and could arise from either the exocrine (ductal and acinar cells) or the endocrine (neuroendocrine cells) components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendoc...

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Main Authors:	Ogbonna, Onyekachi Henry, Garcon, Marie Carmel, Syrigos, Kostas N., Saif, Muhammad Wasif
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855931/

id	pubmed-3855931
recordtype	oai_dc
spelling	pubmed-38559312013-12-17 Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance Ogbonna, Onyekachi Henry Garcon, Marie Carmel Syrigos, Kostas N. Saif, Muhammad Wasif Case Report Background. Pancreatic tumors are rare and could arise from either the exocrine (ductal and acinar cells) or the endocrine (neuroendocrine cells) components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendocrine cells making up more than 30% of the tumor, has been identified. This unique entity has been referred to as mixed acinar-neuroendocrine carcinoma (MANEC). Only about 20 such cases have been reported in the literature. Case Report. We report an interesting case of MANEC with neuroendocrine cell predominance in a woman presenting with epigastric pain secondary to a pancreatic mass with acinar and endocrine differentiation. She underwent surgical resection of the tumor and was offered adjuvant treatment chemotherapy with carboplatin, etoposide, and radiotherapy for positive tumor resection margins. Conclusions. Given the paucity of the cases of MANEC, continuous reporting of these cases when identified should be encouraged to aid oncologists in understanding the disease and help establish standardized management. Hindawi Publishing Corporation 2013 2013-11-17 /pmc/articles/PMC3855931/ /pubmed/24348574 http://dx.doi.org/10.1155/2013/705092 Text en Copyright © 2013 Onyekachi Henry Ogbonna et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ogbonna, Onyekachi Henry Garcon, Marie Carmel Syrigos, Kostas N. Saif, Muhammad Wasif
spellingShingle	Ogbonna, Onyekachi Henry Garcon, Marie Carmel Syrigos, Kostas N. Saif, Muhammad Wasif Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance
author_facet	Ogbonna, Onyekachi Henry Garcon, Marie Carmel Syrigos, Kostas N. Saif, Muhammad Wasif
author_sort	Ogbonna, Onyekachi Henry
title	Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance
title_short	Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance
title_full	Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance
title_fullStr	Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance
title_full_unstemmed	Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance
title_sort	mixed acinar-neuroendocrine carcinoma of the pancreas with neuroendocrine predominance
description	Background. Pancreatic tumors are rare and could arise from either the exocrine (ductal and acinar cells) or the endocrine (neuroendocrine cells) components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendocrine cells making up more than 30% of the tumor, has been identified. This unique entity has been referred to as mixed acinar-neuroendocrine carcinoma (MANEC). Only about 20 such cases have been reported in the literature. Case Report. We report an interesting case of MANEC with neuroendocrine cell predominance in a woman presenting with epigastric pain secondary to a pancreatic mass with acinar and endocrine differentiation. She underwent surgical resection of the tumor and was offered adjuvant treatment chemotherapy with carboplatin, etoposide, and radiotherapy for positive tumor resection margins. Conclusions. Given the paucity of the cases of MANEC, continuous reporting of these cases when identified should be encouraged to aid oncologists in understanding the disease and help establish standardized management.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855931/
_version_	1612036344440160256

Mixed Acinar-Neuroendocrine Carcinoma of the Pancreas with Neuroendocrine Predominance

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