Sertraline inhibits formalin-induced nociception and cardiovascular responses

The objective of the present study was to determine the antihyperalgesic effect of sertraline, measured indirectly by the changes of sciatic afferent nerve activity, and its effects on cardiorespiratory parameters, using the model of formalin-induced inflammatory nociception in anesthetized rats. Se...

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Main Authors:	Santuzzi, C.H., Futuro Neto, H.A., Pires, J.G.P., Gonçalves, W.L.S., Tiradentes, R.V., Gouvea, S.A., Abreu, G.R.
Format:	Online
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854144/

id	pubmed-3854144
recordtype	oai_dc
spelling	pubmed-38541442013-12-16 Sertraline inhibits formalin-induced nociception and cardiovascular responses Santuzzi, C.H. Futuro Neto, H.A. Pires, J.G.P. Gonçalves, W.L.S. Tiradentes, R.V. Gouvea, S.A. Abreu, G.R. Short Communication The objective of the present study was to determine the antihyperalgesic effect of sertraline, measured indirectly by the changes of sciatic afferent nerve activity, and its effects on cardiorespiratory parameters, using the model of formalin-induced inflammatory nociception in anesthetized rats. Serum serotonin (5-HT) levels were measured in order to test their correlation with the analgesic effect. Male Wistar rats (250-300 g) were divided into 4 groups (N = 8 per group): sertraline-treated group (Sert + Saline (Sal) and Sert + Formalin (Form); 3 mg·kg−1·day−1, ip, for 7 days) and saline-treated group (Sal + Sal and Sal + Form). The rats were injected with 5% (50 µL) formalin or saline into the right hind paw. Sciatic nerve activity was recorded using a silver electrode connected to a NeuroLog apparatus, and cardiopulmonary parameters (mean arterial pressure, heart rate and respiratory frequency), assessed after arterial cannulation and tracheotomy, were monitored using a Data Acquisition System. Blood samples were collected from the animals and serum 5-HT levels were determined by ELISA. Formalin injection induced the following changes: sciatic afferent nerve activity (+50.8 ± 14.7%), mean arterial pressure (+1.4 ± 3 mmHg), heart rate (+13 ± 6.8 bpm), respiratory frequency (+4.6 ± 5 cpm) and serum 5-HT increased to 1162 ± 124.6 ng/mL. Treatment with sertraline significantly reduced all these parameters (respectively: +19.8 ± 6.9%, -3.3 ± 2 mmHg, -13.1 ± 10.8 bpm, -9.8 ± 5.7 cpm) and serum 5-HT level dropped to 634 ± 69 ng/mL (P < 0.05). These results suggest that sertraline plays an analgesic role in formalin-induced nociception probably through a serotonergic mechanism. Sociedade Brasileira de Medicina Tropical 2011-11-18 /pmc/articles/PMC3854144/ /pubmed/22086464 http://dx.doi.org/10.1590/S0100-879X2011007500154 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Santuzzi, C.H. Futuro Neto, H.A. Pires, J.G.P. Gonçalves, W.L.S. Tiradentes, R.V. Gouvea, S.A. Abreu, G.R.
spellingShingle	Santuzzi, C.H. Futuro Neto, H.A. Pires, J.G.P. Gonçalves, W.L.S. Tiradentes, R.V. Gouvea, S.A. Abreu, G.R. Sertraline inhibits formalin-induced nociception and cardiovascular responses
author_facet	Santuzzi, C.H. Futuro Neto, H.A. Pires, J.G.P. Gonçalves, W.L.S. Tiradentes, R.V. Gouvea, S.A. Abreu, G.R.
author_sort	Santuzzi, C.H.
title	Sertraline inhibits formalin-induced nociception and cardiovascular responses
title_short	Sertraline inhibits formalin-induced nociception and cardiovascular responses
title_full	Sertraline inhibits formalin-induced nociception and cardiovascular responses
title_fullStr	Sertraline inhibits formalin-induced nociception and cardiovascular responses
title_full_unstemmed	Sertraline inhibits formalin-induced nociception and cardiovascular responses
title_sort	sertraline inhibits formalin-induced nociception and cardiovascular responses
description	The objective of the present study was to determine the antihyperalgesic effect of sertraline, measured indirectly by the changes of sciatic afferent nerve activity, and its effects on cardiorespiratory parameters, using the model of formalin-induced inflammatory nociception in anesthetized rats. Serum serotonin (5-HT) levels were measured in order to test their correlation with the analgesic effect. Male Wistar rats (250-300 g) were divided into 4 groups (N = 8 per group): sertraline-treated group (Sert + Saline (Sal) and Sert + Formalin (Form); 3 mg·kg−1·day−1, ip, for 7 days) and saline-treated group (Sal + Sal and Sal + Form). The rats were injected with 5% (50 µL) formalin or saline into the right hind paw. Sciatic nerve activity was recorded using a silver electrode connected to a NeuroLog apparatus, and cardiopulmonary parameters (mean arterial pressure, heart rate and respiratory frequency), assessed after arterial cannulation and tracheotomy, were monitored using a Data Acquisition System. Blood samples were collected from the animals and serum 5-HT levels were determined by ELISA. Formalin injection induced the following changes: sciatic afferent nerve activity (+50.8 ± 14.7%), mean arterial pressure (+1.4 ± 3 mmHg), heart rate (+13 ± 6.8 bpm), respiratory frequency (+4.6 ± 5 cpm) and serum 5-HT increased to 1162 ± 124.6 ng/mL. Treatment with sertraline significantly reduced all these parameters (respectively: +19.8 ± 6.9%, -3.3 ± 2 mmHg, -13.1 ± 10.8 bpm, -9.8 ± 5.7 cpm) and serum 5-HT level dropped to 634 ± 69 ng/mL (P < 0.05). These results suggest that sertraline plays an analgesic role in formalin-induced nociception probably through a serotonergic mechanism.
publisher	Sociedade Brasileira de Medicina Tropical
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854144/
_version_	1612035743435194368

Sertraline inhibits formalin-induced nociception and cardiovascular responses

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