Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug that suppresses abnormally activated FGFR3 si...

Full description

Bibliographic Details
Main Authors: Matsushita, Masaki, Kitoh, Hiroshi, Ohkawara, Bisei, Mishima, Kenichi, Kaneko, Hiroshi, Ito, Mikako, Masuda, Akio, Ishiguro, Naoki, Ohno, Kinji
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852501/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852501/

Similar Items