A transient reversal of miRNA-mediated repression controls macrophage activation
During macrophage activation, cytokine mRNAs are translated despite high levels of counteracting miRNAs. Here, phosphorylation of Ago2 is shown to impair its binding to miRNAs and cognate mRNAs, enabling macrophage activation and prevention of pathogen invasion.
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851954/ |