The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons☆

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons☆

TDP-43 and FUS are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and loss of function of either protein contributes to these neurodegenerative conditions. To elucidate the TDP-43- and FUS-regulated pathophysiological RNA metabolism cascades, we assessed...

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Bibliographic Details
Main Authors: Honda, Daiyu, Ishigaki, Shinsuke, Iguchi, Yohei, Fujioka, Yusuke, Udagawa, Tsuyoshi, Masuda, Akio, Ohno, Kinji, Katsuno, Masahisa, Sobue, Gen
Format: Online
Language:English
Published: Elsevier 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851184/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851184/

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