Monitoring NK cell activity in patients with hematological malignancies

Natural killer (NK) cells are lymphocytes of the innate immune system that can recognize and kill various types of malignant cells. Monitoring the activity of peripheral NK cells in patients affected by hematological malignancies may provide prognostic information or unveil ongoing tumor-specific im...

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Main Authors:	Viel, Sébastien, Charrier, Emily, Marçais, Antoine, Rouzaire, Paul, Bienvenu, Jacques, Karlin, Lionel, Salles, Gilles, Walzer, Thierry
Format:	Online
Language:	English
Published:	Landes Bioscience 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850490/

id	pubmed-3850490
recordtype	oai_dc
spelling	pubmed-38504902013-12-10 Monitoring NK cell activity in patients with hematological malignancies Viel, Sébastien Charrier, Emily Marçais, Antoine Rouzaire, Paul Bienvenu, Jacques Karlin, Lionel Salles, Gilles Walzer, Thierry Review Natural killer (NK) cells are lymphocytes of the innate immune system that can recognize and kill various types of malignant cells. Monitoring the activity of peripheral NK cells in patients affected by hematological malignancies may provide prognostic information or unveil ongoing tumor-specific immune responses. Moreover, further insights into the biology of NK cells might also promote the development of novel strategies for stimulating their anticancer activity. Here, we review the main methods to monitor phenotypic and functional NK cell properties in cancer patients, focusing on individuals affected by multiple myeloma, a hematological malignancy currently treated with immunomodulatory drugs. Landes Bioscience 2013-09-01 2013-09-12 /pmc/articles/PMC3850490/ /pubmed/24327939 http://dx.doi.org/10.4161/onci.26011 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Viel, Sébastien Charrier, Emily Marçais, Antoine Rouzaire, Paul Bienvenu, Jacques Karlin, Lionel Salles, Gilles Walzer, Thierry
spellingShingle	Viel, Sébastien Charrier, Emily Marçais, Antoine Rouzaire, Paul Bienvenu, Jacques Karlin, Lionel Salles, Gilles Walzer, Thierry Monitoring NK cell activity in patients with hematological malignancies
author_facet	Viel, Sébastien Charrier, Emily Marçais, Antoine Rouzaire, Paul Bienvenu, Jacques Karlin, Lionel Salles, Gilles Walzer, Thierry
author_sort	Viel, Sébastien
title	Monitoring NK cell activity in patients with hematological malignancies
title_short	Monitoring NK cell activity in patients with hematological malignancies
title_full	Monitoring NK cell activity in patients with hematological malignancies
title_fullStr	Monitoring NK cell activity in patients with hematological malignancies
title_full_unstemmed	Monitoring NK cell activity in patients with hematological malignancies
title_sort	monitoring nk cell activity in patients with hematological malignancies
description	Natural killer (NK) cells are lymphocytes of the innate immune system that can recognize and kill various types of malignant cells. Monitoring the activity of peripheral NK cells in patients affected by hematological malignancies may provide prognostic information or unveil ongoing tumor-specific immune responses. Moreover, further insights into the biology of NK cells might also promote the development of novel strategies for stimulating their anticancer activity. Here, we review the main methods to monitor phenotypic and functional NK cell properties in cancer patients, focusing on individuals affected by multiple myeloma, a hematological malignancy currently treated with immunomodulatory drugs.
publisher	Landes Bioscience
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850490/
_version_	1612034199043178496

Monitoring NK cell activity in patients with hematological malignancies

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