Kinetic properties of “dual” orexin receptor antagonists at OX1R and OX2R orexin receptors

Kinetic properties of “dual” orexin receptor antagonists at OX1R and OX2R orexin receptors

Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. Both efficacy and safety are crucial in clinical settings and thorough investigations of pharmacokinetics and pharmacodynamics can predict contributing factors such as duration of act...

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Bibliographic Details
Main Authors: Callander, Gabrielle E., Olorunda, Morenike, Monna, Dominique, Schuepbach, Edi, Langenegger, Daniel, Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Fendt, Markus, Laue, Grit, Ofner, Silvio, Briard, Emmanuelle, Gee, Christine E., Jacobson, Laura H., Hoyer, Daniel
Format: Online
Language:English
Published: Frontiers Media S.A. 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847553/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847553/

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