Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a...

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Main Authors: Gomes, Ana R., Zhao, Fung, Lam, Eric W.F.
Format: Online
Language:English
Published: Sun Yat-sen University Cancer Center 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845605/
id pubmed-3845605
recordtype oai_dc
spelling pubmed-38456052013-12-11 Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance Gomes, Ana R. Zhao, Fung Lam, Eric W.F. Review The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers. Sun Yat-sen University Cancer Center 2013-07 /pmc/articles/PMC3845605/ /pubmed/23706767 http://dx.doi.org/10.5732/cjc.012.10277 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Gomes, Ana R.
Zhao, Fung
Lam, Eric W.F.
spellingShingle Gomes, Ana R.
Zhao, Fung
Lam, Eric W.F.
Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
author_facet Gomes, Ana R.
Zhao, Fung
Lam, Eric W.F.
author_sort Gomes, Ana R.
title Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
title_short Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
title_full Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
title_fullStr Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
title_full_unstemmed Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
title_sort role and regulation of the forkhead transcription factors foxo3a and foxm1 in carcinogenesis and drug resistance
description The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.
publisher Sun Yat-sen University Cancer Center
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845605/
_version_ 1612032341335605248

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