A chronological expression profile of gene activity during embryonic mouse brain development

The brain is a functionally complex organ, the patterning and development of which are key to adult health. To help elucidate the genetic networks underlying mammalian brain patterning, we conducted detailed transcriptional profiling during embryonic development of the mouse brain. A total of 2,400...

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Main Authors:	Goggolidou, P., Soneji, S., Powles-Glover, N., Williams, D., Sethi, S., Baban, D., Simon, M. M., Ragoussis, I., Norris, D. P.
Format:	Online
Language:	English
Published:	Springer US 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843766/

id	pubmed-3843766
recordtype	oai_dc
spelling	pubmed-38437662013-12-04 A chronological expression profile of gene activity during embryonic mouse brain development Goggolidou, P. Soneji, S. Powles-Glover, N. Williams, D. Sethi, S. Baban, D. Simon, M. M. Ragoussis, I. Norris, D. P. Article The brain is a functionally complex organ, the patterning and development of which are key to adult health. To help elucidate the genetic networks underlying mammalian brain patterning, we conducted detailed transcriptional profiling during embryonic development of the mouse brain. A total of 2,400 genes were identified as showing differential expression between three developmental stages. Analysis of the data identified nine gene clusters to demonstrate analogous expression profiles. A significant group of novel genes of as yet undiscovered biological function were detected as being potentially relevant to brain development and function, in addition to genes that have previously identified roles in the brain. Furthermore, analysis for genes that display asymmetric expression between the left and right brain hemispheres during development revealed 35 genes as putatively asymmetric from a combined data set. Our data constitute a valuable new resource for neuroscience and neurodevelopment, exposing possible functional associations between genes, including novel loci, and encouraging their further investigation in human neurological and behavioural disorders. Springer US 2013-11-19 2013 /pmc/articles/PMC3843766/ /pubmed/24249052 http://dx.doi.org/10.1007/s00335-013-9486-7 Text en © The Author(s) 2013 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Goggolidou, P. Soneji, S. Powles-Glover, N. Williams, D. Sethi, S. Baban, D. Simon, M. M. Ragoussis, I. Norris, D. P.
spellingShingle	Goggolidou, P. Soneji, S. Powles-Glover, N. Williams, D. Sethi, S. Baban, D. Simon, M. M. Ragoussis, I. Norris, D. P. A chronological expression profile of gene activity during embryonic mouse brain development
author_facet	Goggolidou, P. Soneji, S. Powles-Glover, N. Williams, D. Sethi, S. Baban, D. Simon, M. M. Ragoussis, I. Norris, D. P.
author_sort	Goggolidou, P.
title	A chronological expression profile of gene activity during embryonic mouse brain development
title_short	A chronological expression profile of gene activity during embryonic mouse brain development
title_full	A chronological expression profile of gene activity during embryonic mouse brain development
title_fullStr	A chronological expression profile of gene activity during embryonic mouse brain development
title_full_unstemmed	A chronological expression profile of gene activity during embryonic mouse brain development
title_sort	chronological expression profile of gene activity during embryonic mouse brain development
description	The brain is a functionally complex organ, the patterning and development of which are key to adult health. To help elucidate the genetic networks underlying mammalian brain patterning, we conducted detailed transcriptional profiling during embryonic development of the mouse brain. A total of 2,400 genes were identified as showing differential expression between three developmental stages. Analysis of the data identified nine gene clusters to demonstrate analogous expression profiles. A significant group of novel genes of as yet undiscovered biological function were detected as being potentially relevant to brain development and function, in addition to genes that have previously identified roles in the brain. Furthermore, analysis for genes that display asymmetric expression between the left and right brain hemispheres during development revealed 35 genes as putatively asymmetric from a combined data set. Our data constitute a valuable new resource for neuroscience and neurodevelopment, exposing possible functional associations between genes, including novel loci, and encouraging their further investigation in human neurological and behavioural disorders.
publisher	Springer US
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843766/
_version_	1612031765695692800

A chronological expression profile of gene activity during embryonic mouse brain development

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