MUTATIONS IN THE GABRB1 GENE PROMOTE ALCOHOL CONSUMPTION THROUGH INCREASED TONIC INHIBITION

MUTATIONS IN THE GABRB1 GENE PROMOTE ALCOHOL CONSUMPTION THROUGH INCREASED TONIC INHIBITION

Alcohol-dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases following mutations to the γ-aminobutyric acidA receptor (GABAAR) β1 subunit gene (Gabrb1). Using N-ethyl-N-nitrosourea mutagenesis on an alcoh...

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Bibliographic Details
Main Authors: Anstee, Quentin M., Knapp, Susanne, Maguire, Edward P., Hosie, Alastair M., Thomas, Philip, Mortensen, Martin, Bhome, Rohan, Martinez, Alonso, Walker, Sophie E., Dixon, Claire I., Ruparelia, Kush, Montagnese, Sara, Kuo, Yu-Ting, Herlihy, Amy, Bell, Jimmy D, Robinson, Iain, Guerrini, Irene, McQuillin, Andrew, Fisher, Elizabeth M.C., Ungless, Mark A., Gurling, Hugh M.D., Morgan, Marsha Y., Brown, Steve D.M., Stephens, David N., Belelli, Delia, Lambert, Jeremy J., Smart, Trevor G., Thomas, Howard C.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843143/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843143/

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