Reliable set-up for in-loop 11C-carboxylations using Grignard reactions for the preparation of [carbonyl-11C]WAY-100635 and [11C]-(+)-PHNO☆

Reliable set-up for in-loop 11C-carboxylations using Grignard reactions for the preparation of [carbonyl-11C]WAY-100635 and [11C]-(+)-PHNO☆

Aim of this work was the implementation of a generalized in-loop synthesis for 11C-carboxylations and subsequent 11C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-11C]WAY-100635 and, for the first time, [11C]-(+)-PHNO. Its general applicability could be demonstr...

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Bibliographic Details
Main Authors: Rami-Mark, Christina, Ungersboeck, Johanna, Haeusler, Daniela, Nics, Lukas, Philippe, Cecile, Mitterhauser, Markus, Willeit, Matthaeus, Lanzenberger, Rupert, Karanikas, Georgios, Wadsak, Wolfgang
Format: Online
Language:English
Published: Pergamon Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842501/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842501/

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