Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

Hyperpolarization-activated cyclic nucleotide–regulated cation (HCN) channels generate the hyperpolarization-activated cation current Ih present in many neurons. These channels are directly regulated by the binding of cAMP, which both shifts the voltage dependence of HCN channel opening to more posi...

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Bibliographic Details
Main Authors: Hu, Lei, Santoro, Bina, Saponaro, Andrea, Liu, Haiying, Moroni, Anna, Siegelbaum, Steven
Format: Online
Language:English
Published: The Rockefeller University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840918/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840918/

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