The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach

The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach

Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population usin...

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Main Authors: McGlinchey, Paul G., Spence, Mark S., Patterson, Chris C., Allen, Adrian R., Murphy, Gillian, Fogarty, Damian, Evans, Alun, McKeown, Pascal P.
Format: Online
Language:English
Published: IOS Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839324/
id pubmed-3839324
recordtype oai_dc
spelling pubmed-38393242013-12-17 The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach McGlinchey, Paul G. Spence, Mark S. Patterson, Chris C. Allen, Adrian R. Murphy, Gillian Fogarty, Damian Evans, Alun McKeown, Pascal P. Other Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD. IOS Press 2004 2005-01-18 /pmc/articles/PMC3839324/ /pubmed/15665388 http://dx.doi.org/10.1155/2004/715745 Text en Copyright © 2004 Hindawi Publishing Corporation.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author McGlinchey, Paul G.
Spence, Mark S.
Patterson, Chris C.
Allen, Adrian R.
Murphy, Gillian
Fogarty, Damian
Evans, Alun
McKeown, Pascal P.
spellingShingle McGlinchey, Paul G.
Spence, Mark S.
Patterson, Chris C.
Allen, Adrian R.
Murphy, Gillian
Fogarty, Damian
Evans, Alun
McKeown, Pascal P.
The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
author_facet McGlinchey, Paul G.
Spence, Mark S.
Patterson, Chris C.
Allen, Adrian R.
Murphy, Gillian
Fogarty, Damian
Evans, Alun
McKeown, Pascal P.
author_sort McGlinchey, Paul G.
title The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_short The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_full The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_fullStr The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_full_unstemmed The Matrix Metalloproteinase-3 (MMP-3) 5A/6A Promoter Polymorphism Is Not Associated with Ischaemic Heart Disease: Analysis Employing a Family Based Approach
title_sort matrix metalloproteinase-3 (mmp-3) 5a/6a promoter polymorphism is not associated with ischaemic heart disease: analysis employing a family based approach
description Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD.
publisher IOS Press
publishDate 2004
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839324/
_version_ 1612030330017939456

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