The Changing Face of Esophageal Cancer
The two main histological esophageal cancer types, adenocarcinoma and squamous cell carcinoma, differ in incidence, geographic distribution, ethnic pattern and etiology. This article focuses on epidemiology with particular reference to geographic and temporal variations in incidence, along with a re...
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| Format: | Online |
| Language: | English |
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MDPI
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837312/ |
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pubmed-38373122013-11-22 The Changing Face of Esophageal Cancer Melhado, Rachel E. Alderson, Derek Tucker, Olga Review The two main histological esophageal cancer types, adenocarcinoma and squamous cell carcinoma, differ in incidence, geographic distribution, ethnic pattern and etiology. This article focuses on epidemiology with particular reference to geographic and temporal variations in incidence, along with a review of the evidence supporting environmental and genetic factors involved in esophageal carcinogenesis. Squamous cell carcinoma of the esophagus remains predominantly a disease of the developing world. In contrast, esophageal adenocarcinoma is mainly a disease of western developed societies, associated with obesity and gastro-esophageal reflux disease. There has been a dramatic increase in the incidence of adenocarcinoma in developed countries in parallel with migration of both esophageal and gastric adenocarcinomas towards the gastro-esophageal junction. MDPI 2010-06-28 /pmc/articles/PMC3837312/ /pubmed/24281163 http://dx.doi.org/10.3390/cancers2031379 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Melhado, Rachel E. Alderson, Derek Tucker, Olga |
| spellingShingle |
Melhado, Rachel E. Alderson, Derek Tucker, Olga The Changing Face of Esophageal Cancer |
| author_facet |
Melhado, Rachel E. Alderson, Derek Tucker, Olga |
| author_sort |
Melhado, Rachel E. |
| title |
The Changing Face of Esophageal Cancer |
| title_short |
The Changing Face of Esophageal Cancer |
| title_full |
The Changing Face of Esophageal Cancer |
| title_fullStr |
The Changing Face of Esophageal Cancer |
| title_full_unstemmed |
The Changing Face of Esophageal Cancer |
| title_sort |
changing face of esophageal cancer |
| description |
The two main histological esophageal cancer types, adenocarcinoma and squamous cell carcinoma, differ in incidence, geographic distribution, ethnic pattern and etiology. This article focuses on epidemiology with particular reference to geographic and temporal variations in incidence, along with a review of the evidence supporting environmental and genetic factors involved in esophageal carcinogenesis. Squamous cell carcinoma of the esophagus remains predominantly a disease of the developing world. In contrast, esophageal adenocarcinoma is mainly a disease of western developed societies, associated with obesity and gastro-esophageal reflux disease. There has been a dramatic increase in the incidence of adenocarcinoma in developed countries in parallel with migration of both esophageal and gastric adenocarcinomas towards the gastro-esophageal junction. |
| publisher |
MDPI |
| publishDate |
2010 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837312/ |
| _version_ |
1612029968658726912 |