Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma

Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma

Metastatic melanoma is characterized by a poor response to chemotherapy. Furthermore, there is a lack of established predictive and prognostic markers. In this single institution study, we correlated mutation status and expression levels of BRAF and NRAS to dacarbazine (DTIC) treatment response as w...

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Bibliographic Details
Main Authors: Birkeland, Einar, Busch, Christian, Berge, Elisabet Ognedal, Geisler, Jürgen, Jönsson, Göran, Lillehaug, Johan Richard, Knappskog, Stian, Lønning, Per Eystein
Format: Online
Language:English
Published: Springer Netherlands 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837233/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837233/

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