A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

The “One world, one health” initiative emphasizes the need for new strategies to control human and animal tuberculosis (TB) based on their shared interface. A good example would be the development of novel universal vaccines against Mycobacterium tuberculosis complex (MTBC) infection. This study use...

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Main Authors: Pérez de Val, Bernat, Vidal, Enric, Villarreal-Ramos, Bernardo, Gilbert, Sarah C., Andaluz, Anna, Moll, Xavier, Martín, Maite, Nofrarías, Miquel, McShane, Helen, Vordermeier, H. Martin, Domingo, Mariano
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836889/
id pubmed-3836889
recordtype oai_dc
spelling pubmed-38368892013-11-25 A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression Pérez de Val, Bernat Vidal, Enric Villarreal-Ramos, Bernardo Gilbert, Sarah C. Andaluz, Anna Moll, Xavier Martín, Maite Nofrarías, Miquel McShane, Helen Vordermeier, H. Martin Domingo, Mariano Research Article The “One world, one health” initiative emphasizes the need for new strategies to control human and animal tuberculosis (TB) based on their shared interface. A good example would be the development of novel universal vaccines against Mycobacterium tuberculosis complex (MTBC) infection. This study uses the goat model, a natural TB host, to assess the protective effectiveness of a new vaccine candidate in combination with Bacillus Calmette-Guerin (BCG) vaccine. Public Library of Science 2013-11-21 /pmc/articles/PMC3836889/ /pubmed/24278420 http://dx.doi.org/10.1371/journal.pone.0081317 Text en © 2013 Pérez de Val et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Pérez de Val, Bernat
Vidal, Enric
Villarreal-Ramos, Bernardo
Gilbert, Sarah C.
Andaluz, Anna
Moll, Xavier
Martín, Maite
Nofrarías, Miquel
McShane, Helen
Vordermeier, H. Martin
Domingo, Mariano
spellingShingle Pérez de Val, Bernat
Vidal, Enric
Villarreal-Ramos, Bernardo
Gilbert, Sarah C.
Andaluz, Anna
Moll, Xavier
Martín, Maite
Nofrarías, Miquel
McShane, Helen
Vordermeier, H. Martin
Domingo, Mariano
A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression
author_facet Pérez de Val, Bernat
Vidal, Enric
Villarreal-Ramos, Bernardo
Gilbert, Sarah C.
Andaluz, Anna
Moll, Xavier
Martín, Maite
Nofrarías, Miquel
McShane, Helen
Vordermeier, H. Martin
Domingo, Mariano
author_sort Pérez de Val, Bernat
title A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression
title_short A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression
title_full A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression
title_fullStr A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression
title_full_unstemmed A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression
title_sort multi-antigenic adenoviral-vectored vaccine improves bcg-induced protection of goats against pulmonary tuberculosis infection and prevents disease progression
description The “One world, one health” initiative emphasizes the need for new strategies to control human and animal tuberculosis (TB) based on their shared interface. A good example would be the development of novel universal vaccines against Mycobacterium tuberculosis complex (MTBC) infection. This study uses the goat model, a natural TB host, to assess the protective effectiveness of a new vaccine candidate in combination with Bacillus Calmette-Guerin (BCG) vaccine.
publisher Public Library of Science
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836889/
_version_ 1612029807995912192

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