The Spindle Assembly Checkpoint works like a rheostat not a toggle-switch

The Spindle Assembly Checkpoint works like a rheostat not a toggle-switch

The Spindle Assembly Checkpoint (SAC) is essential in mammalian mitosis to ensure the equal segregation of sister chromatids1, 2. The SAC generates a Mitotic Checkpoint Complex (MCC) to prevent the Anaphase Promoting Complex/Cyclosome (APC/C) from targeting key mitotic regulators for destruction unt...

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Bibliographic Details
Main Authors: Collin, Philippe, Nashchekina, Oxana, Walker, Rachael, Pines, Jonathon
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836401/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836401/

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