miRNAs confer phenotypic robustness to gene networks by suppressing biological noise

miRNAs are small non-coding RNAs able to modulate target-gene expression. It has been postulated that miRNAs confer robustness to biological processes, but a clear experimental evidence is still missing. Using a synthetic biology approach, we demonstrate that microRNAs provide phenotypic robustness...

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Bibliographic Details
Main Authors: Siciliano, Velia, Garzilli, Immacolata, Fracassi, Chiara, Criscuolo, Stefania, Ventre, Simona, di Bernardo, Diego
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836244/