An Overview of Biomarkers and Molecular Signatures in HCC
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Although most HCCs seem to originate from the accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Long-term survival of HCC pa...
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| Format: | Online |
| Language: | English |
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MDPI
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835106/ |
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pubmed-38351062013-11-21 An Overview of Biomarkers and Molecular Signatures in HCC Yim, Seon-Hee Chung, Yeun-Jun Review Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Although most HCCs seem to originate from the accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Long-term survival of HCC patients is also poor, partly due to HCC recurrence. Although serum alpha-fetoprotein (AFP) level is a useful marker for the detection and monitoring of HCC, AFP levels may remain normal in the patients even with advanced HCC. To identify useful biomarkers for HCC, many studies have been conducted on molecular events such as genetic and epigenetic alterations, and gene expression. This review summarizes recent studies of potential molecular markers for diagnosis and monitoring metastasis or recurrence of HCC. MDPI 2010-05-07 /pmc/articles/PMC3835106/ /pubmed/24281095 http://dx.doi.org/10.3390/cancers2020809 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yim, Seon-Hee Chung, Yeun-Jun |
| spellingShingle |
Yim, Seon-Hee Chung, Yeun-Jun An Overview of Biomarkers and Molecular Signatures in HCC |
| author_facet |
Yim, Seon-Hee Chung, Yeun-Jun |
| author_sort |
Yim, Seon-Hee |
| title |
An Overview of Biomarkers and Molecular Signatures in HCC |
| title_short |
An Overview of Biomarkers and Molecular Signatures in HCC |
| title_full |
An Overview of Biomarkers and Molecular Signatures in HCC |
| title_fullStr |
An Overview of Biomarkers and Molecular Signatures in HCC |
| title_full_unstemmed |
An Overview of Biomarkers and Molecular Signatures in HCC |
| title_sort |
overview of biomarkers and molecular signatures in hcc |
| description |
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Although most HCCs seem to originate from the accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Long-term survival of HCC patients is also poor, partly due to HCC recurrence. Although serum alpha-fetoprotein (AFP) level is a useful marker for the detection and monitoring of HCC, AFP levels may remain normal in the patients even with advanced HCC. To identify useful biomarkers for HCC, many studies have been conducted on molecular events such as genetic and epigenetic alterations, and gene expression. This review summarizes recent studies of potential molecular markers for diagnosis and monitoring metastasis or recurrence of HCC. |
| publisher |
MDPI |
| publishDate |
2010 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835106/ |
| _version_ |
1612029126866108416 |