A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer

We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and ident...

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Main Authors:	Sugie, Tomoharu, Kassim, Kassim Abdelazeem, Takeuchi, Megumi, Hashimoto, Takashi, Yamagami, Kazuhiko, Masai, Yoshikazu, Toi, Masakazu
Format:	Online
Language:	English
Published:	MDPI 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835100/

id	pubmed-3835100
recordtype	oai_dc
spelling	pubmed-38351002013-11-21 A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer Sugie, Tomoharu Kassim, Kassim Abdelazeem Takeuchi, Megumi Hashimoto, Takashi Yamagami, Kazuhiko Masai, Yoshikazu Toi, Masakazu Article We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and identification of SLN fluorescence after meticulous dissection. The subcutaneous lymphatic channels were precisely detected in all cases. SLN identification rate was 99% (408/411) with a mean of 2.3 nodes identified per patient. Thirty-nine cases (9.5%) had SLNs involved and all of them were ICG positive. Thus, the ICG technique has a high SLN identification rate comparable with that of the radioisotope method. MDPI 2010-04-27 /pmc/articles/PMC3835100/ /pubmed/24281090 http://dx.doi.org/10.3390/cancers2020713 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sugie, Tomoharu Kassim, Kassim Abdelazeem Takeuchi, Megumi Hashimoto, Takashi Yamagami, Kazuhiko Masai, Yoshikazu Toi, Masakazu
spellingShingle	Sugie, Tomoharu Kassim, Kassim Abdelazeem Takeuchi, Megumi Hashimoto, Takashi Yamagami, Kazuhiko Masai, Yoshikazu Toi, Masakazu A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
author_facet	Sugie, Tomoharu Kassim, Kassim Abdelazeem Takeuchi, Megumi Hashimoto, Takashi Yamagami, Kazuhiko Masai, Yoshikazu Toi, Masakazu
author_sort	Sugie, Tomoharu
title	A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_short	A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_full	A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_fullStr	A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_full_unstemmed	A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_sort	novel method for sentinel lymph node biopsy by indocyanine green fluorescence technique in breast cancer
description	We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and identification of SLN fluorescence after meticulous dissection. The subcutaneous lymphatic channels were precisely detected in all cases. SLN identification rate was 99% (408/411) with a mean of 2.3 nodes identified per patient. Thirty-nine cases (9.5%) had SLNs involved and all of them were ICG positive. Thus, the ICG technique has a high SLN identification rate comparable with that of the radioisotope method.
publisher	MDPI
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835100/
_version_	1612029124113596416

A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer

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