Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk

Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk

Objectives: Genes encoding for cytokines have been associated with susceptibility for joint osteoarthritis (OA) and interleukin (IL)-1 gene is supposed to be involved in the cartilage destruction process. In this regard, interleukin-1 receptor antagonist (IL-1RA) competing with IL-1 for binding to...

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Main Authors: Swellam, Menha, Mahmoud, Magda Sayed, Samy, Nervana, Gamal, Ali Ahmed
Format: Online
Language:English
Published: IOS Press 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833698/
id pubmed-3833698
recordtype oai_dc
spelling pubmed-38336982013-12-17 Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk Swellam, Menha Mahmoud, Magda Sayed Samy, Nervana Gamal, Ali Ahmed Other Objectives: Genes encoding for cytokines have been associated with susceptibility for joint osteoarthritis (OA) and interleukin (IL)-1 gene is supposed to be involved in the cartilage destruction process. In this regard, interleukin-1 receptor antagonist (IL-1RA) competing with IL-1 for binding to its receptor may act as an inhibitor of cartilage breakdown. We assessed the association of primary knee OA with IL-1RA region as a putative factor of susceptibility to knee OA in Egyptian patients. IOS Press 2010 2010-06-29 /pmc/articles/PMC3833698/ /pubmed/20592454 http://dx.doi.org/10.3233/DMA-2010-0708 Text en Copyright © 2010 Hindawi Publishing Corporation.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Swellam, Menha
Mahmoud, Magda Sayed
Samy, Nervana
Gamal, Ali Ahmed
spellingShingle Swellam, Menha
Mahmoud, Magda Sayed
Samy, Nervana
Gamal, Ali Ahmed
Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk
author_facet Swellam, Menha
Mahmoud, Magda Sayed
Samy, Nervana
Gamal, Ali Ahmed
author_sort Swellam, Menha
title Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk
title_short Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk
title_full Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk
title_fullStr Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk
title_full_unstemmed Potential Influence of Interleukin-1 Receptor Antagonist Gene Polymorphism on Knee Osteoarthritis Risk
title_sort potential influence of interleukin-1 receptor antagonist gene polymorphism on knee osteoarthritis risk
description Objectives: Genes encoding for cytokines have been associated with susceptibility for joint osteoarthritis (OA) and interleukin (IL)-1 gene is supposed to be involved in the cartilage destruction process. In this regard, interleukin-1 receptor antagonist (IL-1RA) competing with IL-1 for binding to its receptor may act as an inhibitor of cartilage breakdown. We assessed the association of primary knee OA with IL-1RA region as a putative factor of susceptibility to knee OA in Egyptian patients.
publisher IOS Press
publishDate 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833698/
_version_ 1612028575748194304

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