Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese

Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese

C-reactive protein (CRP) levels vary remarkably with ethnic status. Its distribution and correlates should be investigated across diverse populations, and these were limited in a representative Chinese population. We investigated 3133 participants aged 18–80 years in Shanghai, which were sampled usi...

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Main Authors: Zhao, Yanfang, Wang, Rui, Ma, Xiuqiang, Yan, Xiaoyan, Zhang, Zhansai, He, Xiang, He, Jia
Format: Online
Language:English
Published: IOS Press 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833416/
id pubmed-3833416
recordtype oai_dc
spelling pubmed-38334162013-12-17 Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese Zhao, Yanfang Wang, Rui Ma, Xiuqiang Yan, Xiaoyan Zhang, Zhansai He, Xiang He, Jia Other C-reactive protein (CRP) levels vary remarkably with ethnic status. Its distribution and correlates should be investigated across diverse populations, and these were limited in a representative Chinese population. We investigated 3133 participants aged 18–80 years in Shanghai, which were sampled using a randomized, stratified, multi-stage sampling method. The distribution of CRP was highly skewed toward a lower level. The median CRP was 0.55 mg/L (0.61 mg/L in males, 0.51 mg/L in females). Participants living in urban region had higher CRP levels than those in rural region (0.67 vs. 0.46 mg/L). CRP levels showed significant correlation with traditional cardiovascular risk factors, and it was most strongly correlated with body mass index. Multivariate logistic regression analyses indicated that elevated CRP (being in the top 15 percentile of CRP; CRP ≥ 2.09 mg/L) was significantly associated with obesity, hypertension, diabetes, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol, high triglycerides and cardiovascular disease history. In conclusion, the distribution of CRP in adult Chinese was comparable with that of many other Asian populations but different from that of Western populations. Metabolic impairment was associated with elevated CRP, and CRP levels should be interpreted in conjunction with the lipid profile. IOS Press 2010 2010-08-02 /pmc/articles/PMC3833416/ /pubmed/20683147 http://dx.doi.org/10.3233/DMA-2010-0713 Text en Copyright © 2010 Hindawi Publishing Corporation.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Zhao, Yanfang
Wang, Rui
Ma, Xiuqiang
Yan, Xiaoyan
Zhang, Zhansai
He, Xiang
He, Jia
spellingShingle Zhao, Yanfang
Wang, Rui
Ma, Xiuqiang
Yan, Xiaoyan
Zhang, Zhansai
He, Xiang
He, Jia
Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese
author_facet Zhao, Yanfang
Wang, Rui
Ma, Xiuqiang
Yan, Xiaoyan
Zhang, Zhansai
He, Xiang
He, Jia
author_sort Zhao, Yanfang
title Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese
title_short Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese
title_full Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese
title_fullStr Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese
title_full_unstemmed Distribution of C-reactive Protein and Its Association with Cardiovascular Risk Factors in a Population-Based Sample of Chinese
title_sort distribution of c-reactive protein and its association with cardiovascular risk factors in a population-based sample of chinese
description C-reactive protein (CRP) levels vary remarkably with ethnic status. Its distribution and correlates should be investigated across diverse populations, and these were limited in a representative Chinese population. We investigated 3133 participants aged 18–80 years in Shanghai, which were sampled using a randomized, stratified, multi-stage sampling method. The distribution of CRP was highly skewed toward a lower level. The median CRP was 0.55 mg/L (0.61 mg/L in males, 0.51 mg/L in females). Participants living in urban region had higher CRP levels than those in rural region (0.67 vs. 0.46 mg/L). CRP levels showed significant correlation with traditional cardiovascular risk factors, and it was most strongly correlated with body mass index. Multivariate logistic regression analyses indicated that elevated CRP (being in the top 15 percentile of CRP; CRP ≥ 2.09 mg/L) was significantly associated with obesity, hypertension, diabetes, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol, high triglycerides and cardiovascular disease history. In conclusion, the distribution of CRP in adult Chinese was comparable with that of many other Asian populations but different from that of Western populations. Metabolic impairment was associated with elevated CRP, and CRP levels should be interpreted in conjunction with the lipid profile.
publisher IOS Press
publishDate 2010
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833416/
_version_ 1612028461205946368

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