Production of a Dominant-Negative Fragment Due to G3BP1 Cleavage Contributes to the Disruption of Mitochondria-Associated Protective Stress Granules during CVB3 Infection

Production of a Dominant-Negative Fragment Due to G3BP1 Cleavage Contributes to the Disruption of Mitochondria-Associated Protective Stress Granules during CVB3 Infection

Stress granules (SGs) are dynamic cytosolic aggregates containing messenger ribonucleoproteins and target poly-adenylated (A)-mRNA. A key component of SGs is Ras-GAP SH3 domain binding protein-1 (G3BP1), which in part mediates protein-protein and protein-RNA interactions. SGs are modulated during in...

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Bibliographic Details
Main Authors: Fung, Gabriel, Ng, Chen Seng, Zhang, Jingchun, Shi, Junyan, Wong, Jerry, Piesik, Paulina, Han, Lillian, Chu, Fanny, Jagdeo, Julienne, Jan, Eric, Fujita, Takashi, Luo, Honglin
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832613/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832613/

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