Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents

Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operation...

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Main Authors:	Ryder, Justin R, Vega-López, Sonia, Djedjos, Constantine S, Shaibi, Gabriel Q
Format:	Online
Language:	English
Published:	BioMed Central 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832228/

id	pubmed-3832228
recordtype	oai_dc
spelling	pubmed-38322282013-11-19 Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents Ryder, Justin R Vega-López, Sonia Djedjos, Constantine S Shaibi, Gabriel Q Short Report Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R2 = 0.13, β = -1.7; p = 0.006; R2 = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R2 = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents. BioMed Central 2013-11-16 /pmc/articles/PMC3832228/ /pubmed/24238302 http://dx.doi.org/10.1186/1758-5996-5-72 Text en Copyright © 2013 Ryder et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ryder, Justin R Vega-López, Sonia Djedjos, Constantine S Shaibi, Gabriel Q
spellingShingle	Ryder, Justin R Vega-López, Sonia Djedjos, Constantine S Shaibi, Gabriel Q Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
author_facet	Ryder, Justin R Vega-López, Sonia Djedjos, Constantine S Shaibi, Gabriel Q
author_sort	Ryder, Justin R
title	Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
title_short	Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
title_full	Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
title_fullStr	Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
title_full_unstemmed	Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
title_sort	abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in latino adolescents
description	Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R2 = 0.13, β = -1.7; p = 0.006; R2 = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R2 = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents.
publisher	BioMed Central
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832228/
_version_	1612027980585893888

Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents

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