Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings
Hard X-ray phase-contrast imaging characterizes the electron density distribution in an object without the need for radiation absorption. The power of phase contrast to resolve subtle changes, such as those in soft tissue structures, lies in its ability to detect minute refractive bending of X-rays....
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| Format: | Online |
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Nature Pub. Group
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831282/ |
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pubmed-3831282 |
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pubmed-38312822013-11-18 Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings Wen, Han Gomella, Andrew A. Patel, Ajay Lynch, Susanna K. Morgan, Nicole Y. Anderson, Stasia A. Bennett, Eric E. Xiao, Xianghui Liu, Chian Wolfe, Douglas E. Article Hard X-ray phase-contrast imaging characterizes the electron density distribution in an object without the need for radiation absorption. The power of phase contrast to resolve subtle changes, such as those in soft tissue structures, lies in its ability to detect minute refractive bending of X-rays. Here we report a far-field, two-arm interferometer based on the new nanometric phase gratings, which can detect X-ray refraction with subnanoradian sensitivity, and at the same time overcomes the fundamental limitation of ultra-narrow bandwidths (Δλ/λ~10−4) of the current, most sensitive methods based on crystal interferometers. On a 1.5% bandwidth synchrotron source, we demonstrate clear visualization of blood vessels in unstained mouse organs in simple projection views, with over an order-of-magnitude higher phase contrast than current near-field grating interferometers. Nature Pub. Group 2013-11-05 /pmc/articles/PMC3831282/ /pubmed/24189696 http://dx.doi.org/10.1038/ncomms3659 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
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Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Wen, Han Gomella, Andrew A. Patel, Ajay Lynch, Susanna K. Morgan, Nicole Y. Anderson, Stasia A. Bennett, Eric E. Xiao, Xianghui Liu, Chian Wolfe, Douglas E. |
| spellingShingle |
Wen, Han Gomella, Andrew A. Patel, Ajay Lynch, Susanna K. Morgan, Nicole Y. Anderson, Stasia A. Bennett, Eric E. Xiao, Xianghui Liu, Chian Wolfe, Douglas E. Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings |
| author_facet |
Wen, Han Gomella, Andrew A. Patel, Ajay Lynch, Susanna K. Morgan, Nicole Y. Anderson, Stasia A. Bennett, Eric E. Xiao, Xianghui Liu, Chian Wolfe, Douglas E. |
| author_sort |
Wen, Han |
| title |
Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings |
| title_short |
Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings |
| title_full |
Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings |
| title_fullStr |
Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings |
| title_full_unstemmed |
Subnanoradian X-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings |
| title_sort |
subnanoradian x-ray phase-contrast imaging using a far-field interferometer of nanometric phase gratings |
| description |
Hard X-ray phase-contrast imaging characterizes the electron density distribution in an object without the need for radiation absorption. The power of phase contrast to resolve subtle changes, such as those in soft tissue structures, lies in its ability to detect minute refractive bending of X-rays. Here we report a far-field, two-arm interferometer based on the new nanometric phase gratings, which can detect X-ray refraction with subnanoradian sensitivity, and at the same time overcomes the fundamental limitation of ultra-narrow bandwidths (Δλ/λ~10−4) of the current, most sensitive methods based on crystal interferometers. On a 1.5% bandwidth synchrotron source, we demonstrate clear visualization of blood vessels in unstained mouse organs in simple projection views, with over an order-of-magnitude higher phase contrast than current near-field grating interferometers. |
| publisher |
Nature Pub. Group |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831282/ |
| _version_ |
1612027810074853376 |