Regulation of Regenerative Periodontal Healing by NAMPT

Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Re...

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Main Authors:	Nokhbehsaim, Marjan, Keser, Sema, Jäger, Andreas, Jepsen, Søren, Deschner, James
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830893/

id	pubmed-3830893
recordtype	oai_dc
spelling	pubmed-38308932013-11-28 Regulation of Regenerative Periodontal Healing by NAMPT Nokhbehsaim, Marjan Keser, Sema Jäger, Andreas Jepsen, Søren Deschner, James Research Article Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased levels of NAMPT have also been found in patients with periodontitis, irrespective of the presence of obesity. This in vitro study sought to examine the effects of NAMPT on the regenerative capacity of human periodontal ligament (PDL) cells and, thereby, periodontal healing. PDL cells treated with enamel matrix derivative (EMD), which was used to mimic regenerative healing conditions in vitro, were grown in the presence and absence of NAMPT for up to 14 d. EMD stimulated significantly (P < 0.05) the expression of growth factors and their receptors, matrix molecules, osteogenesis-associated factors, and wound closure and calcium accumulation. In the presence of NAMPT, all these stimulatory effects were significantly (P < 0.05) reduced. In conclusion, the beneficial effects of EMD on a number of PDL cell functions critical for periodontal regeneration are counteracted by NAMPT. Enhanced levels of NAMPT, as found in obesity and periodontal inflammation, may compromise the regenerative capacity of PDL cells and, thereby, periodontal healing in the presence of EMD. Hindawi Publishing Corporation 2013 2013-10-28 /pmc/articles/PMC3830893/ /pubmed/24288440 http://dx.doi.org/10.1155/2013/202530 Text en Copyright © 2013 Marjan Nokhbehsaim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nokhbehsaim, Marjan Keser, Sema Jäger, Andreas Jepsen, Søren Deschner, James
spellingShingle	Nokhbehsaim, Marjan Keser, Sema Jäger, Andreas Jepsen, Søren Deschner, James Regulation of Regenerative Periodontal Healing by NAMPT
author_facet	Nokhbehsaim, Marjan Keser, Sema Jäger, Andreas Jepsen, Søren Deschner, James
author_sort	Nokhbehsaim, Marjan
title	Regulation of Regenerative Periodontal Healing by NAMPT
title_short	Regulation of Regenerative Periodontal Healing by NAMPT
title_full	Regulation of Regenerative Periodontal Healing by NAMPT
title_fullStr	Regulation of Regenerative Periodontal Healing by NAMPT
title_full_unstemmed	Regulation of Regenerative Periodontal Healing by NAMPT
title_sort	regulation of regenerative periodontal healing by nampt
description	Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased levels of NAMPT have also been found in patients with periodontitis, irrespective of the presence of obesity. This in vitro study sought to examine the effects of NAMPT on the regenerative capacity of human periodontal ligament (PDL) cells and, thereby, periodontal healing. PDL cells treated with enamel matrix derivative (EMD), which was used to mimic regenerative healing conditions in vitro, were grown in the presence and absence of NAMPT for up to 14 d. EMD stimulated significantly (P < 0.05) the expression of growth factors and their receptors, matrix molecules, osteogenesis-associated factors, and wound closure and calcium accumulation. In the presence of NAMPT, all these stimulatory effects were significantly (P < 0.05) reduced. In conclusion, the beneficial effects of EMD on a number of PDL cell functions critical for periodontal regeneration are counteracted by NAMPT. Enhanced levels of NAMPT, as found in obesity and periodontal inflammation, may compromise the regenerative capacity of PDL cells and, thereby, periodontal healing in the presence of EMD.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830893/
_version_	1612027703318282240

Regulation of Regenerative Periodontal Healing by NAMPT

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