Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia

Background. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients. Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients'...

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Main Authors:	Sarris, Katerina, Maltezas, Dimitrios, Koulieris, Efstathios, Bartzis, Vassiliki, Tzenou, Tatiana, Sachanas, Sotirios, Nikolaou, Eftychia, Efthymiou, Anna, Bitsani, Katerina, Dimou, Maria, Vassilakopoulos, Theodoros P., Siakantaris, Marina, Angelopoulou, Maria K., Kontopidou, Flora, Tsaftaridis, Panagiotis, Kafasi, Nikolitsa, Pangalis, Gerasimos A., Panayiotidis, Panayiotis P., Harding, Stephen, Kyrtsonis, Marie-Christine
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830760/

id	pubmed-3830760
recordtype	oai_dc
spelling	pubmed-38307602013-11-28 Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia Sarris, Katerina Maltezas, Dimitrios Koulieris, Efstathios Bartzis, Vassiliki Tzenou, Tatiana Sachanas, Sotirios Nikolaou, Eftychia Efthymiou, Anna Bitsani, Katerina Dimou, Maria Vassilakopoulos, Theodoros P. Siakantaris, Marina Angelopoulou, Maria K. Kontopidou, Flora Tsaftaridis, Panagiotis Kafasi, Nikolitsa Pangalis, Gerasimos A. Panayiotidis, Panayiotis P. Harding, Stephen Kyrtsonis, Marie-Christine Research Article Background. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients. Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients' series. Patients and Methods. We studied 143 CLL patients of which 18 were symptomatic and needed treatment, while 37 became symptomatic during follow-up. Seventy-two percent, 18%, and 10% were in Binet stage A, B and C, respectively. Median patients' followup was 32 months (range 4–228). Results. Increased involved (restricted) sFLC (iFLC) was found in 42% of patients, while the summated FLC-kappa plus FLC-lambda was above 60 mg/dL in 14%. Increased sFLC values as well as those of summated FLC above 60 were related to shorter time to treatment (P = 0.0005 and P = 0.000003, resp.) and overall survival (P = 0.05 and P = 0.003, resp.). They also correlated with β2-microglobulin (P = 0.009 and P = 0.03, resp.), serum albumin (P = 0.009 for summated sFLC), hemoglobin (P < 0.001), abnormal LDH (P = 0.037 and P = 0.001, resp.), Binet stage (P < 0.05) and with the presence of beta symptoms (P = 0.004 for summated sFLC). Conclusion. We confirmed the prognostic significance of sFLC in CLL regarding both time to treatment and survival and showed their relationship with other parameters. Hindawi Publishing Corporation 2013 2013-10-29 /pmc/articles/PMC3830760/ /pubmed/24288537 http://dx.doi.org/10.1155/2013/359071 Text en Copyright © 2013 Katerina Sarris et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sarris, Katerina Maltezas, Dimitrios Koulieris, Efstathios Bartzis, Vassiliki Tzenou, Tatiana Sachanas, Sotirios Nikolaou, Eftychia Efthymiou, Anna Bitsani, Katerina Dimou, Maria Vassilakopoulos, Theodoros P. Siakantaris, Marina Angelopoulou, Maria K. Kontopidou, Flora Tsaftaridis, Panagiotis Kafasi, Nikolitsa Pangalis, Gerasimos A. Panayiotidis, Panayiotis P. Harding, Stephen Kyrtsonis, Marie-Christine
spellingShingle	Sarris, Katerina Maltezas, Dimitrios Koulieris, Efstathios Bartzis, Vassiliki Tzenou, Tatiana Sachanas, Sotirios Nikolaou, Eftychia Efthymiou, Anna Bitsani, Katerina Dimou, Maria Vassilakopoulos, Theodoros P. Siakantaris, Marina Angelopoulou, Maria K. Kontopidou, Flora Tsaftaridis, Panagiotis Kafasi, Nikolitsa Pangalis, Gerasimos A. Panayiotidis, Panayiotis P. Harding, Stephen Kyrtsonis, Marie-Christine Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia
author_facet	Sarris, Katerina Maltezas, Dimitrios Koulieris, Efstathios Bartzis, Vassiliki Tzenou, Tatiana Sachanas, Sotirios Nikolaou, Eftychia Efthymiou, Anna Bitsani, Katerina Dimou, Maria Vassilakopoulos, Theodoros P. Siakantaris, Marina Angelopoulou, Maria K. Kontopidou, Flora Tsaftaridis, Panagiotis Kafasi, Nikolitsa Pangalis, Gerasimos A. Panayiotidis, Panayiotis P. Harding, Stephen Kyrtsonis, Marie-Christine
author_sort	Sarris, Katerina
title	Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia
title_short	Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia
title_full	Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia
title_fullStr	Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia
title_full_unstemmed	Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia
title_sort	prognostic significance of serum free light chains in chronic lymphocytic leukemia
description	Background. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients. Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients' series. Patients and Methods. We studied 143 CLL patients of which 18 were symptomatic and needed treatment, while 37 became symptomatic during follow-up. Seventy-two percent, 18%, and 10% were in Binet stage A, B and C, respectively. Median patients' followup was 32 months (range 4–228). Results. Increased involved (restricted) sFLC (iFLC) was found in 42% of patients, while the summated FLC-kappa plus FLC-lambda was above 60 mg/dL in 14%. Increased sFLC values as well as those of summated FLC above 60 were related to shorter time to treatment (P = 0.0005 and P = 0.000003, resp.) and overall survival (P = 0.05 and P = 0.003, resp.). They also correlated with β2-microglobulin (P = 0.009 and P = 0.03, resp.), serum albumin (P = 0.009 for summated sFLC), hemoglobin (P < 0.001), abnormal LDH (P = 0.037 and P = 0.001, resp.), Binet stage (P < 0.05) and with the presence of beta symptoms (P = 0.004 for summated sFLC). Conclusion. We confirmed the prognostic significance of sFLC in CLL regarding both time to treatment and survival and showed their relationship with other parameters.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830760/
_version_	1612027630885797888

Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia

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