Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

Loss of Fhit expression, encoded at chromosome fragile site FRA3B, leads to increased replication stress, genome instability and accumulation of genetic alterations. We have proposed that Fhit is a genome ‘caretaker’ whose loss initiates genome instability in preneoplastic lesions. We have character...

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Bibliographic Details
Main Authors: Miuma, Satoshi, Saldivar, Joshua C., Karras, Jenna R., Waters, Catherine E., Paisie, Carolyn A., Wang, Yao, Jin, Victor, Sun, Jin, Druck, Teresa, Zhang, Jie, Huebner, Kay
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828255/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828255/

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