Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance

Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance

RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the development of RAS-driven tumors. However, it is unknown whether interaction of RAS with PI3-kinase is required in established tumors. The nee...

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Bibliographic Details
Main Authors: Castellano, Esther, Sheridan, Clare, Thin, May Zaw, Nye, Emma, Spencer-Dene, Bradley, Diefenbacher, Markus E., Moore, Christopher, Kumar, Madhu S., Murillo, Miguel M., Grönroos, Eva, Lassailly, Francois, Stamp, Gordon, Downward, Julian
Format: Online
Language:English
Published: Cell Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826036/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826036/

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