Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis

The prognostic relevance of innate immune cells infiltrating colorectal carcinoma lesions is highly debated. By evaluating the expression of myeloperoxidase (MPO) as a marker of neutrophil granulocytes in a large cohort of colorectal carcinoma specimens, we have observed that robust tumor-infiltrati...

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Main Authors:	Hirt, Christian, Eppenberger-Castori, Serenella, Sconocchia, Giuseppe, Iezzi, Giandomenica, Tornillo, Luigi, Terracciano, Luigi, Spagnoli, Giulio C, Droeser, Raoul A
Format:	Online
Language:	English
Published:	Landes Bioscience 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825723/

id	pubmed-3825723
recordtype	oai_dc
spelling	pubmed-38257232013-11-15 Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis Hirt, Christian Eppenberger-Castori, Serenella Sconocchia, Giuseppe Iezzi, Giandomenica Tornillo, Luigi Terracciano, Luigi Spagnoli, Giulio C Droeser, Raoul A Author's View The prognostic relevance of innate immune cells infiltrating colorectal carcinoma lesions is highly debated. By evaluating the expression of myeloperoxidase (MPO) as a marker of neutrophil granulocytes in a large cohort of colorectal carcinoma specimens, we have observed that robust tumor-infiltration by MPO+ cells correlates with improved patient survival independently of other histopathological parameters, including disease stage. Landes Bioscience 2013-10-01 2013-09-12 /pmc/articles/PMC3825723/ /pubmed/24244897 http://dx.doi.org/10.4161/onci.25990 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hirt, Christian Eppenberger-Castori, Serenella Sconocchia, Giuseppe Iezzi, Giandomenica Tornillo, Luigi Terracciano, Luigi Spagnoli, Giulio C Droeser, Raoul A
spellingShingle	Hirt, Christian Eppenberger-Castori, Serenella Sconocchia, Giuseppe Iezzi, Giandomenica Tornillo, Luigi Terracciano, Luigi Spagnoli, Giulio C Droeser, Raoul A Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
author_facet	Hirt, Christian Eppenberger-Castori, Serenella Sconocchia, Giuseppe Iezzi, Giandomenica Tornillo, Luigi Terracciano, Luigi Spagnoli, Giulio C Droeser, Raoul A
author_sort	Hirt, Christian
title	Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
title_short	Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
title_full	Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
title_fullStr	Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
title_full_unstemmed	Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
title_sort	colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
description	The prognostic relevance of innate immune cells infiltrating colorectal carcinoma lesions is highly debated. By evaluating the expression of myeloperoxidase (MPO) as a marker of neutrophil granulocytes in a large cohort of colorectal carcinoma specimens, we have observed that robust tumor-infiltration by MPO+ cells correlates with improved patient survival independently of other histopathological parameters, including disease stage.
publisher	Landes Bioscience
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825723/
_version_	1612026044977512448

Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis

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