Glutathione Depletion by L-Buthionine-S,R-Sulfoximine Induces Apoptosis of Cardiomyocytes through Activation of PKC-δ
In the present study, we investigated the effect of intracellular glutathione (GSH) depletion in heart-derived H9c2 cells and its mechanism. L-buthionine-S,R-sulfoximine (BSO) induced the depletion of cellular GSH, and BSO-induced reactive oxygen species (ROS) production was inhibited by glutathione...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Korean Society of Applied Pharmacology
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825199/ |