Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Ra...
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| Format: | Online |
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The Korean Society of Applied Pharmacology
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825197/ |
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pubmed-3825197 |
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pubmed-38251972013-11-15 Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin Kim, Bora Lee, Jee-Young Lee, Ha-Yeon Nam, Ky-Youb Park, JongIl Lee, Su Min Kim, Jin Eun Lee, Joo Dong Hwang, Jae Sung Articles We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent. The Korean Society of Applied Pharmacology 2013-09-30 /pmc/articles/PMC3825197/ /pubmed/24244821 http://dx.doi.org/10.4062/biomolther.2013.032 Text en Copyright ©2013, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kim, Bora Lee, Jee-Young Lee, Ha-Yeon Nam, Ky-Youb Park, JongIl Lee, Su Min Kim, Jin Eun Lee, Joo Dong Hwang, Jae Sung |
| spellingShingle |
Kim, Bora Lee, Jee-Young Lee, Ha-Yeon Nam, Ky-Youb Park, JongIl Lee, Su Min Kim, Jin Eun Lee, Joo Dong Hwang, Jae Sung Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin |
| author_facet |
Kim, Bora Lee, Jee-Young Lee, Ha-Yeon Nam, Ky-Youb Park, JongIl Lee, Su Min Kim, Jin Eun Lee, Joo Dong Hwang, Jae Sung |
| author_sort |
Kim, Bora |
| title |
Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin |
| title_short |
Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin |
| title_full |
Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin |
| title_fullStr |
Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin |
| title_full_unstemmed |
Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin |
| title_sort |
hesperidin suppresses melanosome transport by blocking the interaction of rab27a-melanophilin |
| description |
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent. |
| publisher |
The Korean Society of Applied Pharmacology |
| publishDate |
2013 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825197/ |
| _version_ |
1612025898356178944 |