Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆

Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, th...

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Main Authors:	Benetti, Stefania, Pettersson-Yeo, William, Hutton, Chloe, Catani, Marco, Williams, Steve CR, Allen, Paul, Kambeitz-Ilankovic, Lana M, McGuire, Philip, Mechelli, Andrea
Format:	Online
Language:	English
Published:	Elsevier 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824077/

id	pubmed-3824077
recordtype	oai_dc
spelling	pubmed-38240772013-11-12 Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆ Benetti, Stefania Pettersson-Yeo, William Hutton, Chloe Catani, Marco Williams, Steve CR Allen, Paul Kambeitz-Ilankovic, Lana M McGuire, Philip Mechelli, Andrea Article Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P < 0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology. Elsevier 2013-11 /pmc/articles/PMC3824077/ /pubmed/24084578 http://dx.doi.org/10.1016/j.schres.2013.08.030 Text en © 2013 The Authors https://creativecommons.org/licenses/by-nc-sa/3.0/ Open Access under CC BY-NC-SA 3.0 (https://creativecommons.org/licenses/by-nc-sa/3.0/) license
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Benetti, Stefania Pettersson-Yeo, William Hutton, Chloe Catani, Marco Williams, Steve CR Allen, Paul Kambeitz-Ilankovic, Lana M McGuire, Philip Mechelli, Andrea
spellingShingle	Benetti, Stefania Pettersson-Yeo, William Hutton, Chloe Catani, Marco Williams, Steve CR Allen, Paul Kambeitz-Ilankovic, Lana M McGuire, Philip Mechelli, Andrea Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆
author_facet	Benetti, Stefania Pettersson-Yeo, William Hutton, Chloe Catani, Marco Williams, Steve CR Allen, Paul Kambeitz-Ilankovic, Lana M McGuire, Philip Mechelli, Andrea
author_sort	Benetti, Stefania
title	Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆
title_short	Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆
title_full	Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆
title_fullStr	Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆
title_full_unstemmed	Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆
title_sort	elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: a combined voxel-based morphometry and voxel-based cortical thickness study☆
description	Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P < 0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology.
publisher	Elsevier
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824077/
_version_	1612025601344929792

Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study☆

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