Genetic and Acute CPEB Depletion Ameliorate Fragile X Pathophysiology

Genetic and Acute CPEB Depletion Ameliorate Fragile X Pathophysiology

Fragile X Syndrome (FXS), the most common cause of inherited mental retardation and autism, is caused by transcriptional silencing of Fmr1, which encodes the translational repressor protein FMRP. FMRP and CPEB, an activator of translation, are present in neuronal dendrites, are predicted to bind man...

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Bibliographic Details
Main Authors: Udagawa, Tsuyoshi, Farny, Natalie G., Jakovcevski, Mira, Kaphzan, Hanoch, Alarcon, Juan Marcos, Anilkumar, Shobha, Ivshina, Maria, Hurt, Jessica A., Nagaoka, Kentaro, Nalavadi, Vijayalaxmi C., Lorenz, Lori J., Bassell, Gary J., Akbarian, Schahram, Chattarji, Sumantra, Klann, Eric, Richter, Joel D.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823751/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823751/

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