Loss of IKKβ activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis

Loss of IKKβ activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis

Elevated levels of NF-κB are frequently detected in many inflammatory diseases and cancers. Blocking the IKK–NF-κB pathway has been seen as a promising approach for new therapies. By employing the dominant-negative mutant of IKKβ, our data revealed that loss of IKKβ activity reduces not only the pro...

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Bibliographic Details
Main Authors: Yang, Pei-Ming, Huang, Wei-Chien, Lin, Yi-Chu, Huang, Wen-Yu, Wu, Hui-Ann, Chen, Wei-Lun, Chang, Yu-Fan, Chou, Chia-Wei, Tzeng, Cherng-Chyi, Chen, Yeh-Long, Chen, Ching-Chow
Format: Online
Language:English
Published: Blackwell Publishing Ltd 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823466/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823466/

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